15875-50-0

Basic information

• Product Name: 2,2-DIMETHYL-5-(2-THENYLIDENE)-1,3-DIOXANE-4,6-DIONE
• Synonyms: 2,2-DIMETHYL-5-(2-THENYLIDENE)-1,3-DIOXANE-4,6-DIONE;2,2-dimethyl-5-(thiophen-2-ylmethylidene)-1,3-dioxane-4,6-dione
• CAS NO: 15875-50-0
• Molecular Formula: C₁₁H₁₀O₄S
• Molecular Weight: 238.2597
• Mol File: 15875-50-0.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2-DIMETHYL-5-(2-THENYLIDENE)-1,3-DIOXANE-4,6-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYL-5-(2-THENYLIDENE)-1,3-DIOXANE-4,6-DIONE(15875-50-0)
• EPA Substance Registry System: 2,2-DIMETHYL-5-(2-THENYLIDENE)-1,3-DIOXANE-4,6-DIONE(15875-50-0)

Safety Data

• Hazardous Substances Data: 15875-50-0(Hazardous Substances Data)

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 2033-24-1 cycl-isopropylidene malonate 

Downstream Products

• 51019-83-1 (Z)-3-(thiophen-2-yl)acrylic acid 
• 1124-65-8 3-(2-thienyl)-2-propenoic acid 

Relevant articles and documents

2,2-Dimethyl-5-(5-R-2-furfurylidene)-1,3-dioxane-4,6-diones. 4. Synthesis, stereostructures, and properties of thiophene analogs

The reaction of 2-formylthiophenes with Meldrum's acid gave the corresponding thenylidenedioxanediones, which, in contrast to the furfurylidene derivatives, have an s-trans conformation of the mutual orientation of the thiophene ring and the exocyclic double bond. Thenyldioxanediones were synthesized by the selective hydrogenation of the exocyclic double bond.

Organocatalytic kinetic resolution of N-boc-isoxazolidine-5-ones

Easily accessible racemic N-Boc-isoxazolidine-5-ones undergo enantioselective alcoholysis promoted by double hydrogen bond donor amine organocatalysts, resulting in their effective kinetic resolution.

Boron/zinc exchange for the conjugate arylation of unsaturated Meldrum's acid derivatives

An approach for the conjugate arylation reaction of unsaturated Meldrum's acid derivatives is reported. The reaction takes place through a Boron-Zinc exchange reaction between arylboronic acids and diethylzinc and the subsequent transfer of thus generated reactive aryl groups to the β-position of the double bond of the Meldrum's derivatives. The compounds obtained are valuable synthetic intermediates and can give rise to bioactive molecules such as β,β-disubstituted carboxylic acids and amides.

An alternative, practical, and ecological protocol for synthesis of arylidene analogues of Meldrum’s acid as useful intermediates

This paper presents an ecological protocol for Knoevenagel condensation using a catalytic amount of 4,4′-trimethylenedipiperidine as a versatile, efficient, safe, commercially available, inexpensive, and recyclable organocatalyst by a ball-milling process