15875-50-0Relevant articles and documents
2,2-Dimethyl-5-(5-R-2-furfurylidene)-1,3-dioxane-4,6-diones. 4. Synthesis, stereostructures, and properties of thiophene analogs
Krapivin,Kul'nevich,Val'ter
, p. 1118 - 1121 (1990)
The reaction of 2-formylthiophenes with Meldrum's acid gave the corresponding thenylidenedioxanediones, which, in contrast to the furfurylidene derivatives, have an s-trans conformation of the mutual orientation of the thiophene ring and the exocyclic double bond. Thenyldioxanediones were synthesized by the selective hydrogenation of the exocyclic double bond.
Organocatalytic kinetic resolution of N-boc-isoxazolidine-5-ones
Straub, Matthew R.,Birman, Vladimir B.
supporting information, p. 984 - 988 (2021/02/06)
Easily accessible racemic N-Boc-isoxazolidine-5-ones undergo enantioselective alcoholysis promoted by double hydrogen bond donor amine organocatalysts, resulting in their effective kinetic resolution.
Boron/zinc exchange for the conjugate arylation of unsaturated Meldrum's acid derivatives
Jardim, Micaela,Baldassari, Lucas L.,Contreira, Maria Eduarda,Moro, Angélica V.,Lüdtke, Diogo S.
supporting information, (2020/01/31)
An approach for the conjugate arylation reaction of unsaturated Meldrum's acid derivatives is reported. The reaction takes place through a Boron-Zinc exchange reaction between arylboronic acids and diethylzinc and the subsequent transfer of thus generated reactive aryl groups to the β-position of the double bond of the Meldrum's derivatives. The compounds obtained are valuable synthetic intermediates and can give rise to bioactive molecules such as β,β-disubstituted carboxylic acids and amides.
An alternative, practical, and ecological protocol for synthesis of arylidene analogues of Meldrum’s acid as useful intermediates
Khaligh, Nader Ghaffari,Mihankhah, Taraneh,Johan, Mohd Rafie
, (2019/03/17)
This paper presents an ecological protocol for Knoevenagel condensation using a catalytic amount of 4,4′-trimethylenedipiperidine as a versatile, efficient, safe, commercially available, inexpensive, and recyclable organocatalyst by a ball-milling process