158751-64-5Relevant articles and documents
Use of benzenesulfonyl (thioureas or ure as) for treating of septic shock or gene ralized inflammatory syndrome
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, (2008/06/13)
The present invention is directed to the use of a benzenesulfonyl(thiourea or urea) of formula I wherein R1 is hydrogen, (C1-C8)-alkyl-, (C3-C8)-cycloalkyl-, (C3-C8)-cycloalkyl-(C1-C4)-alkyl- or fluoro-(C1-C8)-alkyl-; R2 is (C1-C6)-alkoxy-, (C3-C8)-cycloa
Cardioselective KATP channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas
Englert,Gerlach,Goegelein,Hartung,Heitsch,Mania,Scheidler
, p. 1085 - 1098 (2007/10/03)
Sulfonylthioureas exhibiting cardioselective blockade of ATP-sensitive potassium channels (KATP channels) were discovered by stepwise structural variations of the antidiabetic sulfonylurea glibenclamide. As screening assays, reversal of rilmaka