15878-08-7

Basic information

• Product Name: 4-Chloro-3-Methyl-1H-pyrazole
• Synonyms: Pyrazole,4-chloro-3(or 5)-methyl- (6CI,7CI); Pyrazole, 4-chloro-3-methyl- (8CI);4-Chloro-3-methylpyrazole
• CAS NO: 15878-08-7
• Molecular Formula: C₄H₅ClN₂
• Molecular Weight: 116.5489
• Mol File: 15878-08-7.mol

Chemical Properties

• Boiling Point: 218.1°Cat760mmHg
• Flash Point: 106.4°C
• Appearance: /
• Density: 1.306g/cm³
• Vapor Pressure: 0.189mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 13.27±0.50(Predicted)
• CAS DataBase Reference: 4-Chloro-3-Methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-Methyl-1H-pyrazole(15878-08-7)
• EPA Substance Registry System: 4-Chloro-3-Methyl-1H-pyrazole(15878-08-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37-60
• TSCA: No
• Hazardous Substances Data: 15878-08-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-3-Methyl-1H-pyrazole is used as a building block for the synthesis of pharmaceutical drugs. Its unique chemical structure allows for the development of new drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Chloro-3-Methyl-1H-pyrazole is used as an intermediate for the production of herbicides and pesticides. Its chemical properties enable the creation of effective compounds for controlling weeds and pests in agricultural settings.
Used in Research and Development:
4-Chloro-3-Methyl-1H-pyrazole is utilized in research and development for studying its potential biological activities, such as antimicrobial and anti-inflammatory properties. This research can lead to the discovery of new applications and therapeutic uses for 4-Chloro-3-Methyl-1H-pyrazole.
However, due to its chlorinated nature, the toxicological and environmental effects of 4-Chloro-3-Methyl-1H-pyrazole should be carefully evaluated to ensure its safe and responsible use in various applications.

InChI:InChI=1/C4H5ClN2/c1-3-4(5)2-6-7-3/h2H,1H3,(H,6,7)

Upstream product

• 1453-58-3 3-Methylpyrazole 
• 7791-25-5 sulfuryl dichloride 
• 60-29-7 diethyl ether 
• 56-23-5 tetrachloromethane 
• 7782-50-5 chlorine 

Downstream Products

• 15878-44-1 1,3-Dimethyl-4-chlor-pyrazol 
• 84703-26-4 1,5-dimethyl-4-chloropyrazole 
• 84547-87-5 4-chloro-1H-pyrazole-3-carboxylic acid 
• 1319197-05-1 2-(4-chloro-3-methyl-1H-pyrazol-1-yl)-6-methylaniline 

Relevant articles and documents

3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1

Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Additional halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors.

Substituted piperazines

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Use of low-volatility pyrazole derivatives having hydrophilic groups as nitrification inhibitors

The present invention provides pyrazole compounds which are useful as nitrification inhibitors.

Enzymatic Halogenation of Pyrazoles and Pyridine Derivatives

Pyrazole, 1-methylpyrazole and 3-methylpyrazole are chlorinated by the enzyme chloroperoxidase from Caldariomyces fumago, in the presence of potassium chloride and hydrogen peroxide at pH 2.7, yielding the corresponding 4-chloro derivatives in good yields.A 4H-pyrazole is proposed as an intermediate in this reaction. 2-Aminopyridine was converted regiospecifically by the same enzyme into 2-amino-3-chloropyridine, and 8-hydroxyquinoline gave its 5,7-dibromo-derivatives in very good yield when bromide ion was used as halide substrate.