158792-25-7

Basic information

• Product Name: collismycin B
• Synonyms: collismycin B
• CAS NO: 158792-25-7
• Molecular Formula: C13H13 N3 O2 S
• Molecular Weight: 275.3262
• Mol File: 158792-25-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 381.2°Cat760mmHg
• Flash Point: 184.3°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 5.16E-06mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: collismycin B(CAS DataBase Reference)
• NIST Chemistry Reference: collismycin B(158792-25-7)
• EPA Substance Registry System: collismycin B(158792-25-7)

Safety Data

• Hazardous Substances Data: 158792-25-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H13N3O2S/c1-18-12-7-10(9-5-3-4-6-14-9)16-11(8-15-17)13(12)19-2/h3-8,16H,1-2H3/b11-8-

Upstream product

• 98-98-6 2-Picolinic acid 
• 1416512-50-9 4-methoxy-[2,2']bipyridinyl-6-carboxylic acid diisopropylamide 
• 1416512-49-6 sodium 4-methoxy-[2,2']bipyridinyl-6-carboxylate 
• 14761-58-1 4-methoxy-2,2'-bipyridyl-6-carboxamidoxime 
• 366-18-7 [2,2]bipyridinyl 
• 14163-00-9 4-nitro-2,2'-bipyridine N-oxide 
• 14163-05-4 4-methoxy-2,2’-bipyridine N-oxide 
• 205053-07-2 4-methoxy-5-methylsulfanyl-[2,2′]bipyridinyl-6-carbaldehyde 
• 33421-43-1 2,2'-bipyridyl N-oxide 
• 158792-24-6 collismycin A 
• 205052-97-7 6-bromo-4-nitro-2,2'-bipyridine N-oxide 
• 205053-05-0 6-bromo-4-methoxy-5-(methylthio)-2,2'-bipyridine 
• 205052-91-1 6-bromo-4-methoxy-2,2'-bipyridine N-oxide 
• 205052-93-3 6-bromo-4-methoxy-2,2'-bipyridine 

Relevant articles and documents

Collismycins A and B, novel non-steroidal inhibitors of dexamethasone-glucocorticoid receptor binding [1]

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Generation by mutasynthesis of potential neuroprotectant derivatives of the bipyridyl collismycin A

Collismycin A is a member of the 2,2′-bipyridyl family of natural products and structurally belongs to the hybrid polyketides-nonribosomal peptides. A gene coding for a lysine 2-aminotransferase of Streptomyces sp. CS40 (collismycin A producer) was inactivated by gene replacement. The mutant was unable of synthesizing collismycin A but it recovered this capability when picolinic acid was added to the culture medium. By feeding different picolinic acid analogs to this mutant, two new collismycin A derivatives were obtained with a methyl group at the 4 and 6 position of the first pyridine ring of collismycin A, respectively. The two compounds showed effective neuroprotective action against an oxidative stress inducer in a zebra fish model, one of them showing higher neuroprotectant activity than that of collismycin A and that of the control lipoic acid.