15885-06-0

Upstream product

• 875-30-9 1,3-dimethylindole 
• 78-95-5 chloroacetone 
• 74-89-5 methylamine 
• 100-61-8 N-methylaniline 
• 598-31-2 1-bromoacetone 
• 172984-00-8 1-[(2-Iodo-phenyl)-methyl-amino]-propan-2-one 
• 3233-03-2 1-(N-(methyl)phenylamino)propan-2-ol 
• 56-81-5 glycerol 
• 87-72-9 D-Xylose 
• 73-34-7 6-deoxy-L-galactose 

Downstream Products

• 875-30-9 1,3-dimethylindole 
• 72371-11-0 5-(2-[3-(N-methylanilino)-2-propylamino]-1-hydroxyethyl)-salicylamide 
• 80254-36-0 1,3,6-Trimethyl-5-(methyl-phenyl-amino)-1H-pyrimidine-2,4-dithione 
• 55110-58-2 3-methyl-1-phenyl-2,5-dihydro-1H-pyrrole 
• 95-20-5 2-methyl-1H-indole 
• 1207183-30-9 N₂-cyclopropyl-N₁-methyl-N₁-phenylpropane-1,2-diamine 
• 64-19-7 acetic acid 
• 93-61-8 N-methyl-N-phenylformamide 
• 4293-74-7 3-methyl-1-phenyl-1H-pyrrole 

Relevant academic research and scientific papers

Metal and Oxidant Free Construction of Substituted- and/or Polycyclic Indoles: A Useful Alternative to Bischler and Related Syntheses

A wide range of substituted indoles or polycyclic derivatives containing the indole core are easily accessible by acidic treatment of aromatic amines and 1,2-diaza-1,3-dienes. Unlike the related indole-Bischler synthesis, the regioselectivity of the method here reported is unique and predictable, the yields are generally good and also electron withdrawing substituted indoles are smoothly recovered.

Ru-Catalyzed Switchable N-Hydroxyethylation and N-Acetonylation with Crude Glycerol

Highly efficient Ru-catalyzed selective C?C or C?O bond cleavage of polyols (e.g., crude glycerol) for N-hydroxyethylation or N-acetonylation of amines was achieved through the hydrogen-borrowing approach. A variety of amines were transformed to the desired amino alcohols/ketones in moderate-to-excellent yields, opening up new avenues for generation of oxygenated pharmaceuticals and fine chemicals from renewable raw materials. The use of new redox-active catalysts containing bisphosphine/thienylmethylamine ligands allows this hydrogen-borrowing system to be operated selectively under both basic and acidic conditions.

Direct hydroxyethylation of amines by carbohydrates: Via ruthenium catalysis

An efficient and halogen-free catalytic methodology for the synthesis of β-amino alcohols from aromatic amines and biomass-derived carbohydrates is demonstrated for the first time. The activation of C5/C6 sugars by a ruthenium catalyst selectively generates the C2 alkylating reagent glycolaldehyde. The transformation involves metal-catalyzed hydrogen borrowing for the reduction of the imine intermediate. A series of arylamines bearing various substituents were successfully transformed into the desired products in good to excellent yields.

Preparation method of N-acetonyl amine compound

The invention discloses a preparation method of an N-acetonyl amine compound. The method comprises the following steps that an amine compound and glycerin are used as reaction raw materials, and in the presence of a composite catalyst and an alkali addition agent, in reaction mediums and at the reaction temperature of 80-180 DEG C, a reaction is performed for 2-48 hours in a sealed reactor so that the N-acetonyl amine compound is obtained. The method disclosed by the invention is simple, reaction conditions are mild, target products can be obtained at a low cost and at a high yield, and the used catalyst has high catalytic activity and is easy to separate and repeatedly use in a reaction system; besides, the whole process is environment-friendly, and the utilization of by-products namely the glycerin of biologic diesel oil is promoted.

Bioconjugatable azo-based dark-quencher dyes: Synthesis and application to protease-activatable far-red fluorescent probes

We describe the efficient synthesis and one-step derivatization of novel, nonfluorescent azo dyes based on the Black Hole Quencher-3 (BHQ-3) scaffold. These dyes were equipped with various reactive and/or bioconjugatable groups (azido, α-iodoacetyl, keton

A NEW SYNTHESIS OF 3-SUBSTITUTED INDOLINES AND INDOLES

3-Phenyl- and 3-alkyl-3-hydroxyindolines were synthesized by intramolecular Barbier reaction of phenyl and alkyl N-(2-iodophenyl)-N-methylaminomethyl ketones with n-BuLi, which were easily prepared from N-methyl-2-iodoaniline and bromomethyl ketones.The treatment of the indolines with acid gave the corresponding indoles in quantitative yields.

Synthesis and Properties of Cyclic Keto Alkenylammonium Salts

The cyclic keto alkenylammonium salts (4)-(8) have been prepared by a short, general route and their acidic and electrophilic properties examined.