1588522-94-4

Basic information

• Product Name: N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide
• Synonyms: N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide
• CAS NO: 1588522-94-4
• Molecular Weight: 625.171
• Mol File: 1588522-94-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide(1588522-94-4)
• EPA Substance Registry System: N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide(1588522-94-4)

Safety Data

• Hazardous Substances Data: 1588522-94-4(Hazardous Substances Data)

Upstream product

• 1213269-26-1 4-(3-aminophenoxy)-5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl) pyrimidin-2-amine 
• 1213269-25-0 5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)pyrimidin-2-amine 
• 76661-24-0 2,5-dichloro-4-(3-nitrophenoxy)pyrimidine 
• 554-84-7 meta-nitrophenol 
• 122833-04-9 2-methoxy-4-(4-methylpiperazin-1-yl)aniline 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 446-36-6 5-fluoro-2-nitrophenol 
• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 1213269-23-8 N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide 

Relevant articles and documents

Synthesis and evaluation of 2-anilinopyrimidines bearing 3-aminopropamides as potential epidermal growth factor receptor inhibitors

Novel compounds 12a-i were synthesized and biologically evaluated. Several ones exhibited stronger inhibitory activity than gefitinib against EGFR L858R/T790M and antiproliferative effects on H1975 and HCC827 cells. The 3-aminopropamide in compounds like 12h could be converted to the active acrylamide in the presence of arginine. Importantly, 12h showed improved stability relative to compound 1 whose structure is same to 12h excepting an acrylamide moiety. Interestingly, 12i, a NO donating compound of 12h, showed more potent and selective inhibition than 12h on H1975 cells. Significantly, 12i produced high levels of NO in H1975 cells but not in non-tumorous 16HBE cells, and its inhibition was diminished by NO scavenger. Furthermore, 12i dose-dependently produced inhibitory effects on EGFR downstream signaling in H1975 cells.