158862-62-5

Basic information

• Product Name: 6-(3-pyridinylmethoxy)indole
• Synonyms: 6-(3-pyridinylmethoxy)indole
• CAS NO: 158862-62-5
• Molecular Weight: 224.262
• Mol File: 158862-62-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(3-pyridinylmethoxy)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(3-pyridinylmethoxy)indole(158862-62-5)
• EPA Substance Registry System: 6-(3-pyridinylmethoxy)indole(158862-62-5)

Safety Data

• Hazardous Substances Data: 158862-62-5(Hazardous Substances Data)

Upstream product

• 3099-31-8 nicotinyl chloride 
• 2380-86-1 6-hydroxy-1H-indole 

Relevant articles and documents

3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a Novel Series of Platelet Activating Factor Antagonists

(2RS,4R)-3-(2-(3-pyridinyl)thiazolidin-4-oyl)indoles represent a new class of potent, orally active antagonists of platelet activating factor (PAF). The compounds were prepared by acylation of the magnesium or zinc salts of substituted indoles with (2RS,4R)-2-(3-pyridinyl)-3-(tert-butoxycarbonyl)thiazolidin-4-oyl chloride. The 3-acylindole moiety functions as a hydrolytically stabilized and conformationally restricted anilide replacement, which imparts a considerable boost in potency to the series. Structure-activity relationships observed for substitution on the indole ring system are discussed. Members of the series compare favorably with other reported PAF antagonists.