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Usage

Uses

Used in Pharmaceutical Industry:
1-(2-amino-5-chlorophenyl)-4-chloro-1-Butanone is used as an intermediate for the production of pharmaceuticals. Its unique structure allows it to be a key component in the synthesis of various medicinal compounds, contributing to the development of new drugs and therapies.
Used in Agrochemical Industry:
This chemical compound is also utilized as an intermediate in the production of agrochemicals. Its role in creating effective pesticides and other agricultural products helps improve crop protection and yield.
Used in Chemical Synthesis:
1-(2-amino-5-chlorophenyl)-4-chloro-1-Butanone serves as a reagent in organic synthesis, particularly for the creation of dyes, pigments, and other organic compounds. Its versatility in chemical reactions makes it a valuable asset in the development of a wide range of products.
Used as a Building Block in Organic Synthesis:
Due to its potential as a building block, 1-(2-amino-5-chlorophenyl)-4-chloro-1-Butanone is employed in the synthesis of complex organic molecules. Its integration into more intricate chemical structures opens up possibilities for the creation of advanced materials and compounds with specific applications in various industries.

Upstream product

• 106-47-8 4-chloro-aniline 
• 5500-21-0 cyclopropropanecarbonitrile 
• 628-20-6 4-Chlorobutyronitrile 

Downstream Products

• 150879-49-5 cyclopropyl (4-chloroanilin-2-yl)-ketone 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of an Indazole-Based Selective Protein Arginine Deiminase 4 (PAD4) Inhibitor

Protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme that catalyzes the conversion of arginine to citrulline within target proteins. Dysregulation of PAD4 has been implicated in a number of human diseases, including rheumatoid arthritis and other inflammatory diseases as well as cancer. In this study, we report on the design, synthesis, and evaluation of a new class of haloacetamidine-based compounds as potential PAD4 inhibitors. Specifically, we describe the identification of 4,5,6-trichloroindazole 24 as a highly potent PAD4 inhibitor that displays >10-fold selectivity for PAD4 over PAD3 and >50-fold over PAD1 and PAD2. The efficacy of this compound in cells was determined by measuring the inhibition of PAD4-mediated H4 citrullination in HL-60 granulocytes.

Synthesis of a New Generation Reverse Transcriptase Inhibitor via the BCl3/GaCl3-induced Condensation of Anilines with Nitriles (Sugasawa Reaction)

The synthesis of 1 was achieved in high overall yield through a mechanism-based improvement of the preparation of o-acyl anilines.

In situ NMR spectroscopic studies of aniline ortho acylation ("sugasawa reaction"): The nature of reaction intermediates and Lewis acid influence on yield

Ortho acylation of anilines by nitriles in the presence of BCl3 and a second Lewis acid appear to proceed through an intermediate "supercomplex" including all four components. Yield improvements were obtained based on recognition that chloride affinity of the second Lewis acid governs supercomplex formation. Aniline protonation was found to be the cause of incomplete reaction.