15888-80-9

Upstream product

• 108-94-1 cyclohexanone 
• 103-85-5 monophenylthiourea 
• 18418-42-3 phenyl-dithiocarbamic acid; sodium salt 
• 1074-52-8 ammonium phenyldithiocarbamate 
• 51034-34-5 potassium aniline dithiocarbamate 
• 1226922-89-9 C₅H₅N*C₇H₇NS₂ 
• 43009-16-1 phenyldithiocarbamic acid triethylamine salt 
• 7647-01-0 hydrogenchloride 
• 46493-65-6 3-phenyl-4,5,6,7-tetrahydro-3H-benzothiazol-2-ylideneamine 
• 822-87-7 2-Chlorocyclohexanone 
• 101112-24-7 N-(3-phenyl-4,5,6,7-tetrahydro-3H-benzothiazol-2-ylidene)-acetamide 

Relevant academic research and scientific papers

CuBr2 mediated synthesis of 2-Aminothiazoles from dithiocarbamic acid salts and ketones

In a one-pot procedure, CuBr2 has been used as a efficient desulfurizing agent in the synthesis of 2-aminothiazoles by the condensation of in situ-generated 1-substituted thioureas from their dithiocarbamic acid salts, with in situ-generated α-bromoketones from ketones. All reactions were carried out under optimized reaction conditions and gave the target products in 61–95% yield.

Condensed Tetrahydrobenzothiazoles: Part I- Synthesis of 2-Substituted Anilino-4,5,6,7-tetrahydrobenzothiazoles and Their 4-Carbethoxy Derivatives

Condensation of the appropriate 2-halocyclohexanone (I) with arylthiourea (II) affords a number of 2-substituted anilino-4,5,6,7-tetrahydrobenzothiazoles (IIIa) and their 4-carbethoxy esters (IIIb).Influence of steric factors and nucleophilicity of the reactants on the course of this reaction are discussed.