15889-32-4

Usage

Uses

Used in Organic Synthesis:
2-(3-Aminophenyl)pyridine is utilized as a key building block in the synthesis of various organic compounds. Its unique structure allows for the formation of diverse chemical entities, contributing to the advancement of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-(3-Aminophenyl)pyridine is recognized for its potential as a ligand in coordination chemistry, which can lead to the development of new pharmaceutical agents with improved properties and therapeutic effects.
Used in Materials Science:
2-(3-AMINOPHENYL)PYRIDINE also finds application in materials science, where its structural features can be exploited to design and synthesize new materials with specific properties for various applications.
Used in Anticancer Research:
2-(3-Aminophenyl)pyridine is studied for its potential as an anti-cancer agent. Its pharmacological properties are of interest to researchers who aim to develop novel therapeutics for the treatment of cancer.

InChI:InChI=1/C11H10N2/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h1-8H,12H2

Upstream product

• 4253-79-6 2-(3-nitrophenyl)pyridine 
• 109-04-6 2-bromo-pyridine 
• 30418-59-8 3-Aminophenylboronic acid 
• 626-01-7 3-Iodoaniline 
• 142-08-5 2-hydroxypyridin 
• 645-00-1 m-iodonitrobenzene 
• 1008-89-5 2-phenylpyridine 
• 13331-27-6 m-nitrobenzene boronic acid 
• 109-09-1 2-chloropyridine 
• 17997-47-6 2-tri-n-butylstannylpyridine 
• 591-19-5 m-Bromoaniline 
• 99-03-6 1-(3-aminophenyl)ethanone 
• 109-76-2 Trimethylenediamine 
• 85006-23-1 3-aminophenylboronic acid hydrochloric salt 

Downstream Products

• 57976-24-6 2-[(3-Pyridin-2-yl-phenylamino)-methylene]-malonic acid diethyl ester 
• 1386928-01-3 1-[3-(pyridin-2-yl)phenyl]piperazine 
• 1546890-15-6 C₂₈H₂₁N₃ 
• 1546890-05-4 C₃₄H₂₅N₃ 
• 1432666-69-7 C₂₂H₁₇N₃ 
• 1056016-04-6 2-chloro-6-[3-(2-pyridyl)phenylamino]-9-iso-propylpurine 
• 1056016-06-8 DRF 053 
• 1190221-03-4 5-chloro-2-([(2-oxo-2-([3-(pyridin-2-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid sodium salt 
• 1190222-04-8 methyl 5-chloro-2-{[(2-oxo-2-{[3-(pyridin-2-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate 

Relevant academic research and scientific papers

Characteristics of polymer light emitting diode using a phosphorescent terpolymer containing perylene, triazine and ir(ppy)3 moieties in the polymer side chain

We have synthesized a novel nonconjugated phosphorescent terpolymer, PPPMA-co-DTPM-co-Ir(ppy)3, containing perylene and Ir complex moieties as lightemitting units and a triazine moiety as electron transporting unit in the polymer side chain. Th

Introducing of a New Bio-inspired Hierarchical Porous Silica as an Inorganic Host for Ni–Pd Alloy Nanoparticles for the Synthesis of Aminobiphenyls from the One-Pot Suzuki–Miyaura Coupling-Nitro Reduction

This work reports a facial way to synthesize of an efficient catalyst based Ni–Pd alloy nanoparticles which supported on a new bio-inspired hierarchical porous silica and its catalytic activity in the one-pot Suzuki–Miyaura cross coupling-nitro reduction. The synthesized catalyst was fully characterized by FT-IR, XRD, FESEM–EDX, elemental mapping, TEM, ICP-AES, N2 adsorption–desorption, DRS–UV–Vis and XPS techniques. Use of inexpensive catalyst, high yields of the products and reusability of the catalyst are some of the advantages of our procedure. Graphical Abstract: [Figure not available: see fulltext.].

The two isomers of a cyclometallated palladium sensitizer show different photodynamic properties in cancer cells

This report demonstrates that changing the position of the carbon-metal bond in a polypyridyl cyclopalladated complex, i.e. going from PdL1 (N^N^C^N) to PdL2 (N^N^N^C), dramatically influences the photodynamic properties of the compl

ARYL AND HETEROARYL COMPOUNDS, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF GALACTOCEREBROSIDASE

The application is directed to compounds of formulae (IA) and (IB): (IA) and (IB), and their salts and solvates, wherein R1a, R2a, A1, A2, A3, A4, R1b, R2b, B1, B2, B3, and G are as set forth in the specification, as well as to methods for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of, e.g., lysosomal storage diseases, such as Krabbe's disease, and α-synucleinopathies, such as Parkinson's disease.

ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES

The present invention includes novel heteroleptic/homoleptic iridium complexes containing two tridentate ligands, where at least one of the tridentate ligands comprises of pyridinium-derived N-heterocyclic carbene. The compounds of the present invention may be useful for organic electroluminescent devices.

Preparation methods of Vismodegib and intermediate of Vismodegib

The invention provides preparation methods of Vismodegib and an intermediate of the Vismodegib, namely, preparation methods of 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)benzamide and an intermediate of the 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)benzamide. According to the preparation methods, the intermediate, namely 2-chloro-4-methylsulfonyl-N-(3-(2-pyridinyl)phenyl)benzamide is prepared firstly, and then the 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)benzamide is prepared through a chlorination reaction. The preparation methods have the characteristics that the steps are short, operation is easy, starting materials are cheap and easy to obtain, no palladium reagent is used, the reaction condition has the low requirements for the anhydrous and oxygen-free condition, and the production cost can be effectively lowered.

Organic metal compounds and organic light emitting diodes comprising the same

PURPOSE: An organic metal compound is provided to have excellent thermal properties and light emitting efficiency, thereby being useful for a display and lighting device. CONSTITUTION: An organic metal compound is represented by chemical formula 1. In chemical formula 1, each of R and Z is hydrogen, deuterium, cyano, halogen hydroxy, nitro, C1-40 alkyl, C1-40 alkoxy, C1-40 alkylamino, C6-40 arylamino, C3-40 heteroarylamino, C1-40 alkoxy group, C1-40 alkylamino, C6-40 aryl group, C3-40 aryloxy group, germanium, phosphorous, and boron; each of A, B, C, D, and E is a substituted or unsubstituted aromatic cycle, or substituted or unsubstituted hydrocycle, X is carbon or nitrogen, G is chemical bond or C1-4 alkylene which can be substituted by (R-Zi)n.

Copper mediated C-H amination with oximes: En route to primary anilines

Here we report an efficient Cu(i)-mediated C-H amination reaction with oximes as amino donors to introduce NH2 groups directly. Various strongly coordinating heterocycles including quinoline, pyrimidine, pyrazine, pyrazole and triazole were tolerated well. The potential utility was further demonstrated in a late-stage modification of telmisartan (an antagonist for the angiotensin II receptor).

Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution

Allosteric modulators of the cannabinoid CB1 receptor have recently been reported as an alternative approach to modulate the CB1 receptor for therapeutic benefits. In this study, we report the design and synthesis of a series of diarylureas derived from PSNCBAM-1 (2). Similar to 2, these diarylureas dose-dependently inhibited CP55,940-induced intracellular calcium mobilization and [35S]GTP-γ-S binding while enhancing [3H]CP55,940 binding to the CB1 receptor. Structure-activity relationship studies revealed that the pyridinyl ring of 2 could be replaced by other aromatic rings and the pyrrolidinyl ring is not required for CB1 allosteric modulation. 34 (RTICBM-74) had similar potencies as 2 in all in vitro assays but showed significantly improved metabolic stability to rat liver microsomes. More importantly, 34 was more effective than 2 in attenuating the reinstatement of extinguished cocaine-seeking behavior in rats, demonstrating the potential of this diarylurea series as promising candidates for the development of relapse treatment of cocaine addiction.

Meta-Selective CAr-H Nitration of Arenes through a Ru3(CO)12-Catalyzed Ortho-Metalation Strategy

The first example of transition metal-catalyzed meta-selective CAr-H nitration of arenes is described. With the use of Ru3(CO)12 as the catalyst and Cu(NO3)2·3H2O as the nitro source, a wide spectrum of arenes bearing diversified N-heterocycles or oximido as the directing groups were nitrated with meta-selectivity exclusively. Mechanism studies have demonstrated the formation of a new 18e-octahedral ruthenium species as a key ortho-CAr-H metalated intermediate, which may be responsible for the subsequent meta-selective electrophilic aromatic substitution (SEAr). Moreover, this approach provides a fast-track strategy for atom/step economical synthesis of many useful pharmaceutical molecules.