15889-58-4Relevant academic research and scientific papers
Catalytic asymmetric alkynylation and arylation of aldehydes by an H 8-binaphthyl-based amino alcohol ligand
Ruan, Jiwu,Lu, Gui,Xu, Lijing,Li, Yue-Ming,Chan, Albert S. C.
experimental part, p. 76 - 84 (2009/04/11)
A novel chiral H8-1,1'-binaphthyl-based amino alcohol ligand (1Ra,2S,3R)-2 has been synthesized and applied in the direct nucleophilic addition of organozincs (alkynylzinc and arylzinc prepared in situ) to aldehydes, yielding the corresponding optically active propargylic alcohols and diarylmethanols in high yields and good to excellent enantioselectivities. For the asymmetric arylation reaction, one catalyst (1Ra,2S,3R)-2 can afford both enantiomers of many pharmaceutically interesting diarylmethanols by a proper combination of various arylzinc reagents and aldehydes.
Synthesis of Some Itaconates via Wittig Reaction
Awad, William I.,Kandile, Nadia G.,Wassef, Wasfy N.,Mohamed, Mansoura I.
, p. 405 - 410 (2007/10/02)
The Wittig reaction of aromatic aldehydes with 1,2-bis-(ethoxycarbonyl) ethylidene triphenyl phosphorane (1) furnished oily mixtures of the two diastereomeric products (E) and (Z) (2).Alkaline hydrolysis of the diesters followed by fractional crystallizat
