956-41-2

Basic information

• Product Name: 2-(4-METHOXY-BENZYL)-SUCCINIC ACID
• Synonyms: 2-(4-METHOXY-BENZYL)-SUCCINIC ACID;2-(4-methoxybenzyl)butanedioic acid
• CAS NO: 956-41-2
• Molecular Formula: C₁₂H₁₄O₅
• Molecular Weight: 238.23656
• Mol File: 956-41-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-METHOXY-BENZYL)-SUCCINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHOXY-BENZYL)-SUCCINIC ACID(956-41-2)
• EPA Substance Registry System: 2-(4-METHOXY-BENZYL)-SUCCINIC ACID(956-41-2)

Safety Data

• Hazardous Substances Data: 956-41-2(Hazardous Substances Data)

Usage

General Description

2-(4-Methoxy-benzyl)-succinic acid is a compound with the molecular formula C13H16O5. It is a derivative of succinic acid, with a benzyl group and a methoxy group attached to the succinic acid molecule. This chemical is commonly used in organic synthesis and medicinal chemistry, and it has potential applications in pharmaceutical research for the development of new drugs. It is also used as a building block in the synthesis of various biologically active compounds. The compound may have potential therapeutic properties, and further research is being conducted to explore its potential uses in medicine and pharmacology.

Upstream product

• 857232-37-2 3-(4-methoxy-phenyl)-propane-1,2,2-tricarboxylic acid 
• 17988-20-4 (4-methoxy-benzyl)-trimethyl-silane 
• 110-16-7 maleic acid 
• 104-01-8 4-Methoxyphenylacetic acid 
• 764-42-1 1,2-Dicyanoethylene 
• 75-05-8 acetonitrile 
• 824-94-2 p-methoxybenzyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 6335-37-1 2-(4-methoxybenzyl)malonic acid diethyl ester 
• 6768-23-6 diethyl-2-(4-methoxybenzylidene)malonate 
• 15889-58-4 ((E)-4-methoxy-benzylidene)-succinic acid 
• 15542-71-9 3-(4-methoxy-phenyl)-propane-1,2,2-tricarboxylic acid triethyl ester 
• 104-93-8 p-methylanizole 
• 15159-48-5 2,4-oxetanedione 

Downstream Products

• 59715-88-7 6β,6'β-[(Ξ)-2-(4-methoxy-benzyl)-succinyldiamino]-bis-penicillanic acid 
• 886-30-6 (4-methoxy-benzyl)-succinic acid anhydride 

Relevant articles and documents

TiO2-photocatalyzed reactions of some benzylic donors

TiO2-photocatalyzed oxidation of toluene (1a), benzyltrimethylsilane (1b), and 4-methoxybenzyltrimethylsilane (1c) has been carried out in acetonitrile under oxygen, under nitrogen, and in the presence of electrophilic alkenes under various conditions (using Ag2SO 4 as electron acceptor, adding 2.5% H2O, changing solvent to CH2Cl2). Benzyl radicals, formed via electron transfer and fragmentation, are trapped. A good material balance is often obtained. The overall efficiency of the process depends on the donor Eox, on the rate of fragmentation of the radical cation, and on the acceptor present (Ag+ is an efficient oxidant, an electrophilic alkene a poor one, O2 is intermediate). With ring-unsubstituted benzyl derivatives 1a and 1b, oxidative fragmentation occurs mainly close to the catalyst surface. The benzyl radicals form at a high local concentration and give benzaldehyde under O2, bibenzyl under N2 and dibenzylated derivatives by attack on the alkenes (acrylonitrile, fumaronitrile, maleic acid). In this case, using CH2Cl2-O2 enhances the yield of benzaldehyde. With methoxylated 1c, however, the radical cation migrates into the solution before fragmentation and, therefore, the free benzyl radical is formed. This radical in part is oxidized to the cation, giving a considerable amount of benzylacetamide (or of the alcohol with water), and in part is trapped by the alkenes. The last reaction is less efficient in this case and yields monobenzyl derivatives.

Solar light induced carbon-carbon bond formation via TiO2 photocatalysis

Solar light irradiation of a TiO2 suspension in MeCN containing maleic anhydride and 4-methoxybenzyl(trimethyl)silane gives benzylated succinic acid (or anhydride) on a gram scale.