158948-97-1Relevant academic research and scientific papers
Effect of XlogP and Hansen Solubility Parameters on Small Molecule Modified Paclitaxel Anticancer Drug Conjugates Self-Assembled into Nanoparticles
Zhong, Ting,Hao, Yan-Li,Yao, Xin,Zhang, Shuang,Duan, Xiao-Chuan,Yin, Yi-Fan,Xu, Mei-Qi,Guo, Yang,Li, Zhan-Tao,Zheng, Xiu-Chai,Li, Hui,Zhang, Xuan
, p. 437 - 444 (2018/03/01)
Small molecule modified anticancer drug conjugates (SMMDCs) can self-assemble into nanoparticles (NPs) as therapeutic NP platforms for cancer treatment. Here we demonstrate that the XlogP and Hansen solubility parameters of paclitaxel (PTX) SMMDCs is essential for SMMDCs self-assembling into NPs. The amorphous state of PTX SMMDCs will also affect SMMDCs self-assembling into NPs. However, the antitumor activity of these PTX SMMDCs NPs decreased along with their XlogP values, indicating that a suitable XlogP value for designing the SMMDCs is important for self-assembling into NPs and for possessing antitumor activity. For higher level XlogP SMMDCs, a degradable linker should be considered in the design of SMMDCs to overcome the problem of lower antitumor activity. It is preferable that the hydrophilic groups in the SMMDCs should be present on the surface of self-assembling NPs.
Method and compositions for preparing a compound using a benzoylating agent essentially free of ring chlorination
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Page/Page column 3-4, (2010/10/19)
This invention relates to methods and compositions for preparing compounds using a benzoylating agent essentially free of ring chlorination. In one alternative embodiment, the present invention relates to methods and compositions for preparing taxanes essentially free of ring chlorinated impurities. In another alternative embodiment, the present invention comprises methods of converting taxane amine with a benzoylating agent essentially free of ring chlorination.
SELECTIVE ACYLATION OF SECONDARY HYDROXYL GROUPS
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Page/Page column 26-27, (2008/06/13)
The invention provides methods and compositions for selectively acylating a specific hydroxyl group in a molecule of interest containing at least two unprotected secondary hydroxyl groups. Although the methods and compositions of the invention have genera
