1589503-93-4

Usage

Uses

Used in Pharmaceutical Industry:
1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-aminophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione is used as a potential therapeutic agent for [application reason] due to its complex molecular structure and the presence of various functional groups that may interact with biological targets.
Used in Chemical Research:
In the field of chemical research, 1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-aminophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione serves as a valuable compound for studying the effects of its structural components on biological activity and potential applications in drug development.
Used in Material Science:
1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-6-(4-aminophenyl)thiophene[2,3-d]pyrimidine-2,4(1H,3H)-dione may also find applications in material science, where its unique structural features could be exploited for the development of novel materials with specific properties, such as optoelectronic or sensing applications.

Upstream product

• 1313714-59-8 (E/Z)-2-cyano-3-methyl-4-(4-nitrophenyl)but-2-enoic acid ethyl ester 
• 174072-89-0 2-Amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester 
• 5332-96-7 1-(4-nitrophenyl)propan-2-one 
• 697-73-4 2,6-difluorobenzyl chloride 

Downstream Products

• 737789-87-6 TAK-385 

Relevant academic research and scientific papers

Nitrogen-containing heteroaryl substituted pyrimidinedione compound and application thereof

The invention belongs to the technical field of medicines, and relates to a nitrogen-containing heteroaryl substituted pyrimidinedione compound and application thereof, and a pharmaceutical composition containing the compound, and the nitrogen-containing heteroaryl substituted pyrimidinedione compound and the pharmaceutical composition can be used as gonadotropin releasing hormone receptor antagonists. The invention also relates to a method for preparing the compound and the pharmaceutical composition, and application of the compound and the pharmaceutical composition in prevention or treatment of sex hormone dependent diseases including but not limited to prostate cancer, endometriosis, hysteromyoma, precocious puberty and the like.

Intermediate of relugolian and preparation method and application thereof

The invention discloses brand-new intermediates (including compounds shown in formulas B, C, D and E) of relugolian. The brand-new intermediates can be used for preparing relugolian and salts, derivatives or analogues of relugolian. The invention also discloses a preparation method of the rugolian, the preparation method is simple, the raw materials are easy to obtain, the content of a product uret byproduct is less than 0.10%, the purification cost of a crude product can be greatly reduced, and large-scale production is facilitated.

Relugolix synthesis method

The present invention provides a method for preparing a relugolix intermediate compound 8. The method comprises: (a) carrying out a reaction on a compound 2 and N,N'-carbonyldiimidazole to obtain a compound 3; (b) carrying out a reaction on the compound 3 and 2,6-difluorobenzyl chloride to obtain a compound 4; (c) carrying out a reaction on the compound 4 and 3-amino-6-methoxypyridazine to obtaina compound 5; (d) carrying out a reaction on the compound 5 and N,N'-carbonyldiimidazole to obtain a compound 6; (e) carrying out a reaction on the compound 6, N-bromosuccinimide and azobisisobutyronitrile to obtain a compound 7; and (f) carrying out a reaction on the compound 7 and dimethylamine hydrochloride to obtain a compound 8. The invention further provides a relugolix preparation method, which comprises: (g) carrying out a reaction on the compound 8 obtained by the method and hydrogen under a catalyst to obtain a compound 9; and (h) carrying out a reaction on the compound 9, N,N'-carbonyldiimidazole and methoxy amine hydrochloride to obtain relugolix. According to the present invention, the method adopts the route sequentially comprising loop closing and coupling, such that the method has characteristics of simple operation, less side-reaction, mild reaction condition, high yield, high product purity and easy product purification, and is suitable for commercial scale production.