1589518-93-3

Upstream product

• 108-42-9 3-chloro-aniline 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 

Downstream Products

• 1589519-14-1 3-chloro-N-(2,2,2-trifluoro-1-vinylethyl)aniline 
• 1589519-16-3 C₁₂H₁₃ClF₃N 
• 1589519-15-2 C₁₁H₁₁ClF₃N 
• 1589519-13-0 C₁₅H₁₉ClF₃N 
• 1589519-12-9 C₁₄H₁₇ClF₃N 
• 1589519-11-8 C₁₂H₁₅ClF₃N 
• 1589519-10-7 C₁₂H₁₅ClF₃N 
• 1589519-09-4 C₁₁H₁₃ClF₃N 
• 351-45-1 3-chloro-N-(2,2,2-trifluoroethyl)aniline 
• 1007223-30-4 3-Chloro-N-[1-(trifluoromethyl)ethyl]aniline 

Relevant academic research and scientific papers

One-Pot Synthesis of Functionalized β-Fluoroalkylated Mannich-Type Products from N-Aryl N,O-Acetals

A variety of functionalized β-amino-β-fluoroalkyl carbonyl compounds are accessible via a novel one-pot Mannich-type reaction of CF2- and CF3-containing N-aryl N,O-acetals with lithium enolates of ketones, esters, and nitriles. The resulting β-fluoroalkylated β-aminocarbonyl compounds are promising peptide surrogates to be used in drug development and for biological applications.