351-45-1Relevant academic research and scientific papers
Iron porphyrin-catalyzedN-trifluoroethylation of anilines with 2,2,2-trifluoroethylamine hydrochloride in aqueous solution
Guo, Cancheng,Guo, Yongjia,Liu, Qiang,Ren, Shuang,Xu, Guiming
, p. 20322 - 20325 (2021/06/26)
An iron porphyrin-catalyzedN-trifluoroethylation of anilines has been developed with 2,2,2-trifluoroethylamine hydrochloride as the fluorine source. This one-pot N-H insertion reaction is conductedviacascade diazotization/N-trifluoroethylation reactions.
Method of catalyzing trifluoro-ethylation of aromatic primary amine by ferriporphyrin
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Page/Page column 17, (2019/01/08)
The invention provides a method of catalyzing trifluoro-ethylation of aromatic primary amine by ferriporphyrin. The method comprises the following steps: adding trifluoroethylamine salt and nitrite toa diazo-reaction first and then adding aromatic primary
NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS
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Page/Page column 38, (2017/03/21)
The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
Synthesis of functionalized α-trifluoroethyl amine scaffolds via Grignard addition to N-aryl hemiaminal ethers
Deutsch, Amrei,Glas, Herbert,Hoffmann-Roeder, Anja,Deutsch, Carl
, p. 9288 - 9291 (2014/03/21)
The synthesis of a variety of α-branched trifluoroethyl amines was achieved by reaction of N-aryl hemiaminal ethers with organomagnesium reagents.
