158958-76-0Relevant academic research and scientific papers
Metal-free regioselective bromination of imidazo-heteroarenes: The dual role of an organic bromide salt in electrocatalysis
Raha Roy, Sudipta,Roy, Vishal Jyoti,Sen, Partha Pratim
supporting information, p. 5687 - 5695 (2021/08/16)
This paper represents an electrochemical transformation by demonstrating the dual role of an organic bromide salt, i.e., tetra-n-butylammonium bromide (TBAB), as a brominating agent and as an electrolyte for the regioselective bromination of several imida
Preparation method of C-3 haloimidazolium [1,2-a] pyridine derivative
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Paragraph 0030-0031, (2022/01/08)
The present invention discloses a method for preparing a C-3 haloimidazolium [1,2-a] pyridine derivative, belonging to the field of organic synthesis. The method took imidazolium [1,2-a] pyridine as the starting material, halide cuprous as the halogen sou
Difluorinative-hydroxylation and C-3 functionalization (halogenation/SCN/NO) of imidazopyridine using Selectfluor as fluorine source or oxidant respectively
Balasubramanian, Sridhar,Kalari, Saradhi,Rode, Haridas B.
supporting information, (2021/04/15)
An efficient route for the difluorinative-hydroxylation through dearomative difunctionalization of imidazopyridine using Selectfluor as fluorine source has been developed in an aqueous medium. The reaction proceeds through ionic followed by radical pathwa
Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes
Neto, José S. S.,Balaguez, Renata A.,Franco, Marcelo S.,de Sá Machado, Victor C.,Saba, Sumbal,Rafique, Jamal,Galetto, Fábio Z.,Braga, Antonio L.
supporting information, p. 3410 - 3415 (2020/07/30)
Herein, we describe an efficient, rapid and benign protocol for the direct C(sp2)-H bond halogenation (Cl, Br, I) of 2-arylimidazo[1,2-a]pyridines using trihaloisocyanuric acids in ethanol. Furthermore, this sustainable protocol was successfull
Ultrasound-Promoted and Base-Mediated Regioselective Bromination of Imidazo[1,2- a ]pyridines with Pyridinium Tribromide
Jiang, Hongmei,Guo, Dingyi,Zhang, Yixin,Shen, Qin-Peng,Tang, Shiyun,You, Junheng,Huo, Yi,Wang, Huixian,Gui, Qing-Wen
, p. 2713 - 2720 (2020/09/15)
By using pyridinium tribromide as the bromo source, an efficient- and practical protocol for the synthesis of C3-brominated imidazo-[1,2- a ]pyridines through ultrasound-promoted and Na 2CO 3-mediated regioselective bromination of im
Chemodivergent synthesis of: N -(pyridin-2-yl)amides and 3-bromoimidazo[1,2- a] pyridines from α-bromoketones and 2-aminopyridines
Liu, Yanpeng,Lu, Lixue,Zhou, Haipin,Xu, Feijie,Ma, Cong,Huang, Zhangjian,Xu, Jinyi,Xu, Shengtao
, p. 34671 - 34676 (2019/11/13)
N-(Pyridin-2-yl)amides and 3-bromoimidazo[1,2-a]pyridines were synthesized respectively from α-bromoketones and 2-aminopyridine under different reaction conditions. N-(Pyridin-2-yl)amides were formed in toluene via C-C bond cleavage promoted by I2/s
Hypervalent Iodine Mediated Efficient Solvent-Free Regioselective Halogenation and Thiocyanation of Fused N -Heterocycles
Alla, Manjula,Indukuri, Divakar Reddy,Potuganti, Gal Reddy
, p. 1573 - 1579 (2019/08/07)
A facile, rapid, metal-free regioselective halogenation and thiocyanation of imidazo[1,2- a ]pyridine/pyrimidine heterocycles has been achieved under solvent-free reaction conditions. Halogenations and thiocyanation of the heterocycles could be accomplish
K2S2O8-Mediated halogenation of 2-arylimidazo[1,2-a]pyridines using sodium halides as the halogen sources
Katrun, Praewpan,Kuhakarn, Chutima
supporting information, p. 989 - 993 (2019/03/11)
A convenient halogenation of 2-arylimidazo[1,2-a]pyridines using sodium chloride/bromide/iodide as the halogen sources in the presence of K2S2O8 as an easy-to-handle oxidizing agent was developed. The present work offers a
Synergy of Anodic Oxidation and Cathodic Reduction Leads to Electrochemical C—H Halogenation
Zhou, Zhilin,Yuan, Yong,Cao, Yangmin,Qiao, Jin,Yao, Anjin,Zhao, Jing,Zuo, Wanqing,Chen, Wenjie,Lei, Aiwen
supporting information, p. 611 - 615 (2019/05/10)
We herein uncovered an electrochemical C—H halogenation protocol that synergistically combines anodic oxidation and cathodic reduction for C—X bond formation. The reaction was demonstrated under exogenous-oxidant-free conditions. Moreover, this is the first example of activating CBr4, CHBr3, and CCl3Br under electrochemical conditions.
Copper-Mediated Aerobic Oxidative Synthesis of 3-Bromo-imidazo[1,2-a]pyridines with Pyridines and Enamides
Zhou, Xiaoqiang,Yan, Hao,Ma, Chaowei,He, Yongqin,Li, Yamin,Cao, Jinhui,Yan, Rulong,Huang, Guosheng
, p. 25 - 31 (2016/01/15)
A conversion of pyridines and enamides for the synthesis of 3-bromo-imidazo[1,2-a]pyridines was developed by copper-mediated aerobic oxidative coupling in a one-pot manner. This procedure tolerates various functional groups and affords a series of 3-bromo
