158958-76-0Relevant academic research and scientific papers
Metal-free regioselective bromination of imidazo-heteroarenes: The dual role of an organic bromide salt in electrocatalysis
Raha Roy, Sudipta,Roy, Vishal Jyoti,Sen, Partha Pratim
supporting information, p. 5687 - 5695 (2021/08/16)
This paper represents an electrochemical transformation by demonstrating the dual role of an organic bromide salt, i.e., tetra-n-butylammonium bromide (TBAB), as a brominating agent and as an electrolyte for the regioselective bromination of several imida
Preparation method of C-3 haloimidazolium [1,2-a] pyridine derivative
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Paragraph 0030-0031, (2022/01/08)
The present invention discloses a method for preparing a C-3 haloimidazolium [1,2-a] pyridine derivative, belonging to the field of organic synthesis. The method took imidazolium [1,2-a] pyridine as the starting material, halide cuprous as the halogen sou
Difluorinative-hydroxylation and C-3 functionalization (halogenation/SCN/NO) of imidazopyridine using Selectfluor as fluorine source or oxidant respectively
Balasubramanian, Sridhar,Kalari, Saradhi,Rode, Haridas B.
supporting information, (2021/04/15)
An efficient route for the difluorinative-hydroxylation through dearomative difunctionalization of imidazopyridine using Selectfluor as fluorine source has been developed in an aqueous medium. The reaction proceeds through ionic followed by radical pathwa
Ultrasound-Promoted and Base-Mediated Regioselective Bromination of Imidazo[1,2- a ]pyridines with Pyridinium Tribromide
Jiang, Hongmei,Guo, Dingyi,Zhang, Yixin,Shen, Qin-Peng,Tang, Shiyun,You, Junheng,Huo, Yi,Wang, Huixian,Gui, Qing-Wen
, p. 2713 - 2720 (2020/09/15)
By using pyridinium tribromide as the bromo source, an efficient- and practical protocol for the synthesis of C3-brominated imidazo-[1,2- a ]pyridines through ultrasound-promoted and Na 2CO 3-mediated regioselective bromination of im
Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes
Neto, José S. S.,Balaguez, Renata A.,Franco, Marcelo S.,de Sá Machado, Victor C.,Saba, Sumbal,Rafique, Jamal,Galetto, Fábio Z.,Braga, Antonio L.
supporting information, p. 3410 - 3415 (2020/07/30)
Herein, we describe an efficient, rapid and benign protocol for the direct C(sp2)-H bond halogenation (Cl, Br, I) of 2-arylimidazo[1,2-a]pyridines using trihaloisocyanuric acids in ethanol. Furthermore, this sustainable protocol was successfull
Hypervalent Iodine Mediated Efficient Solvent-Free Regioselective Halogenation and Thiocyanation of Fused N -Heterocycles
Alla, Manjula,Indukuri, Divakar Reddy,Potuganti, Gal Reddy
supporting information, p. 1573 - 1579 (2019/08/07)
A facile, rapid, metal-free regioselective halogenation and thiocyanation of imidazo[1,2- a ]pyridine/pyrimidine heterocycles has been achieved under solvent-free reaction conditions. Halogenations and thiocyanation of the heterocycles could be accomplish
Chemodivergent synthesis of: N -(pyridin-2-yl)amides and 3-bromoimidazo[1,2- a] pyridines from α-bromoketones and 2-aminopyridines
Liu, Yanpeng,Lu, Lixue,Zhou, Haipin,Xu, Feijie,Ma, Cong,Huang, Zhangjian,Xu, Jinyi,Xu, Shengtao
, p. 34671 - 34676 (2019/11/13)
N-(Pyridin-2-yl)amides and 3-bromoimidazo[1,2-a]pyridines were synthesized respectively from α-bromoketones and 2-aminopyridine under different reaction conditions. N-(Pyridin-2-yl)amides were formed in toluene via C-C bond cleavage promoted by I2/s
K2S2O8-Mediated halogenation of 2-arylimidazo[1,2-a]pyridines using sodium halides as the halogen sources
Katrun, Praewpan,Kuhakarn, Chutima
supporting information, p. 989 - 993 (2019/03/11)
A convenient halogenation of 2-arylimidazo[1,2-a]pyridines using sodium chloride/bromide/iodide as the halogen sources in the presence of K2S2O8 as an easy-to-handle oxidizing agent was developed. The present work offers a
Synergy of Anodic Oxidation and Cathodic Reduction Leads to Electrochemical C—H Halogenation
Zhou, Zhilin,Yuan, Yong,Cao, Yangmin,Qiao, Jin,Yao, Anjin,Zhao, Jing,Zuo, Wanqing,Chen, Wenjie,Lei, Aiwen
supporting information, p. 611 - 615 (2019/05/10)
We herein uncovered an electrochemical C—H halogenation protocol that synergistically combines anodic oxidation and cathodic reduction for C—X bond formation. The reaction was demonstrated under exogenous-oxidant-free conditions. Moreover, this is the first example of activating CBr4, CHBr3, and CCl3Br under electrochemical conditions.
Copper-Mediated Aerobic Oxidative Synthesis of 3-Bromo-imidazo[1,2-a]pyridines with Pyridines and Enamides
Zhou, Xiaoqiang,Yan, Hao,Ma, Chaowei,He, Yongqin,Li, Yamin,Cao, Jinhui,Yan, Rulong,Huang, Guosheng
, p. 25 - 31 (2016/01/15)
A conversion of pyridines and enamides for the synthesis of 3-bromo-imidazo[1,2-a]pyridines was developed by copper-mediated aerobic oxidative coupling in a one-pot manner. This procedure tolerates various functional groups and affords a series of 3-bromo
