208118-80-3

Basic information

• Product Name: N-[1-(4-CHLORO-PHENYL)-VINYL]-ACETAMIDE
• Synonyms: N-[1-(4-CHLORO-PHENYL)-VINYL]-ACETAMIDE
• CAS NO: 208118-80-3
• Molecular Formula: C₁₀H₁₀ClNO
• Molecular Weight: 195.6455
• Mol File: 208118-80-3.mol
• Article Data: 34

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-[1-(4-CHLORO-PHENYL)-VINYL]-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-(4-CHLORO-PHENYL)-VINYL]-ACETAMIDE(208118-80-3)
• EPA Substance Registry System: N-[1-(4-CHLORO-PHENYL)-VINYL]-ACETAMIDE(208118-80-3)

Safety Data

• Hazardous Substances Data: 208118-80-3(Hazardous Substances Data)

Upstream product

• 1956-39-4 4-chloroacetophenone oxime 
• 108-24-7 acetic anhydride 
• 5202-78-8 acetylaminoethylene 
• 29540-84-9 4-chlorophenyl trifluoromethanesulfonate 
• 623-03-0 4-Cyanochlorobenzene 
• 917-54-4 methyllithium 
• 917-64-6 methyl magnesium iodide 
• 64-19-7 acetic acid 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 128720-50-3 1-(4-chlorophenyl)ethan-1-imine 
• 91633-32-8 1-azido-1-(p-chlorophenyl)ethane 
• 536-74-3 phenylacetylene 
• 99-91-2 para-chloroacetophenone 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 186296-21-9 (S)-N-[1-(4-chlorophenyl)ethyl]acetamide 
• 92520-15-5 N-[1-(4-chlorophenyl)ethyl]acetamide 
• 960371-80-6 bis(4-methoxyphenyl) (R)-2-(1-(4-chlorophenyl)-1-oxopentan-3-yl)malonate 
• 960371-75-9 bis(4-methoxyphenyl) (R)-2-(4-(4-chlorophenyl)-4-oxobutan-2-yl)malonate 
• 186296-21-9 C₁₀H₁₂ClNO 
• 1310320-97-8 N-acetyl-1-methyl-1-(4-chlorophenyl)allylamine 
• 880876-85-7 3,3’-[1-(4-chlorophenyl)ethane-1,1-diyl]bis(1H-indole) 
• 1604842-49-0 C₁₆H₁₆ClNO₄ 
• 95139-42-7 5-(4-chlorophenyl)-2,3-diphenyl-1H-pyrrole 
• 111787-84-9 ethyl 5-(4-chlorophenyl)-2-methylfuran-3-carboxylate 
• 43020-12-8 1-(5-(4-chlorophenyl)-2-methylfuran-3-yl)ethanone 
• 73402-88-7 2-phenyl-4-(4-chlorophenyl)quinoline 
• 1414365-79-9 1-benzyl-4-(4-chlorophenyl)-2-phenyl-1H-imidazole 

Relevant articles and documents

Visible-light-promoted olefinic trifluoromethylation of enamides with CF3SO2Na

A visible-light-promoted olefinic C-H trifluoromethylation of enamides was developed by employing cheap and stable Langlois’ reagent as the CF3source. A series of β-CF3enamides were obtained in moderate to good yields with highE-isomer selectivity under mild conditions. Preliminary mechanistic studies suggest that molecular oxygen acts as the terminal oxidant for this net oxidative process, and theEisomer selectivity could be well explained by a base-assisted deprotonation of the cation intermediate.

Access to multi-functionalized oxazolines via silver-catalyzed heteroannulation of enamides with sulfoxonium ylides

Disclosed herein is an efficient Ag-catalyzed [4 + 1] heteroannulation reaction of enamides with α-carbonyl sulfoxonium ylides. The diastereoselective transformation provides a practical access to a diverse range of multi-functionalized oxazoline derivatives. The synthetic utility of the resultant tetra-substituted oxazolines is further demonstrated by a series of useful manipulations into valuable building blocks of pharmaceutical relevance.

Selective Dehydrogenative Acylation of Enamides with Aldehydes Leading to Valuable β-Ketoenamides

We have presented a unique example of dehydrogenative acylation of enamides with aldehydes enabled by an earth-abundant iron catalyst. The protocol provides the straightforward access to valuable β-ketoenamides with ample substrate scope and excellent functional group tolerance. Notably, distinct C-H acylation of enamide rather than at N-H moiety site occurs with absolute Z-selectivity was observed. Late-stage modifications of complex molecules and versatile synthetic utility of β-ketoenamides further highlight the practicability of this transformation.