158977-76-5Relevant academic research and scientific papers
2-HETEROARYL-3-OXO-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES FOR THE TREATMENT OF CANCER
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Page/Page column 86, (2018/09/08)
The present invention covers 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I), in which X, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
Synthesis and pharmacological screening of pyrazolo[3,4-c]pyridazine derivatives
Zabska, Ryszarda,Kolodziejczyk, Alicja,Sieklucka-Dziuba, Maria,Morawska, Dorota,Kleinrok, Zdzislaw
, p. 305 - 310 (2007/10/03)
Ethyl 3-chloro-6-(4-chlorophenyl)-pyridazine-4-carboxylate [VII] was cyclized with some nucleophilic reagents (hydrazine hydrate or N-monosubstituted hydrazines) to the new derivatives of pyrazolo[3,4-c]pyridazine [IXa-d]. The structures of the novel compounds were confirmed by elemental and spectral analyses. The effect of several synthesized derivatives on the central nervous system was studied.
Synthesis of pyridazine acetic acid derivatives possessing aldose reductase inhibitory activity and antioxidant properties
Coudert,Albuisson,Boire,Duroux,Bastide,Couquelet
, p. 471 - 477 (2007/10/02)
N-Acetic acid derivatives of 4-carboxy-6-arylpyridazin-3-ones were synthesized for the dual purpose of inhibiting aldose reductase and exhibiting antioxidant properties. All the prepared compounds showed a significant in vitro aldose reductase inhibitory
