213838-29-0

Upstream product

• 64-17-5 ethanol 
• 124500-02-3 α-cyano-β-(p-chlorobenzoyl)propionic acid 
• 105-53-3 diethyl malonate 
• 1073-67-2 4-vinylbenzyl chloride 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 213838-32-5 N-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl)-4-(4-chlorophenyl)-2,2-diethoxycarbonyl-4-oxo-2-thiobutanamide 
• 220287-26-3 ethyl 6-(4-chlorophenyl)-4,5-dihydro-3-okso-2H-pyridazin-4-carboxylate 
• 213838-36-9 5-(4-Chloro-phenyl)-2-thioxo-1-((2R,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-1,2-dihydro-pyrrole-3,3-dicarboxylic acid diethyl ester 
• 220287-28-5 ethyl 3-chloro-6-(4-chlorophenyl)-pyridazine-4-carboxylate 
• 220287-27-4 6-(4-chlorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid 
• 158977-76-5 ethyl 6-(4-chlorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxylate 

Relevant academic research and scientific papers

Cu(OAc)2-Triggered Cascade Reaction of Malonate-Tethered Acyl Oximes with Indoles, Indole-2-alcohols, and Indole-2-carboxamides

A Cu(OAc)2-promoted cascade reaction of malonate-tetherd acyl oximes with indoles, indole-2-alcohols, or indole-2-carboxmides provides facile access to polysubstituted 3-pyrrolin-2-ones. The reaction features the generation of two adjacent elec

TBAI/TBHP-Promoted Generation of Malonyl Radicals: Oxidative Coupling with Styrenes Leads to γ-Keto Diesters

A metal-free protocol for oxidative coupling of malonic esters with styrenes to form γ-keto diesters has been developed. Key to the success of this process is the generation of malonyl radicals from unfunctionalized malonic esters under organo-catalysis conditions with TBAI and TBHP. This process tolerates both terminal and internal olefins with diverse malonic esters. It provides a new green metal-free alternative to traditional metal mediated process for generation of malonyl radicals and there by γ-keto diesters.

Synthesis and pharmacological screening of pyrazolo[3,4-c]pyridazine derivatives

Ethyl 3-chloro-6-(4-chlorophenyl)-pyridazine-4-carboxylate [VII] was cyclized with some nucleophilic reagents (hydrazine hydrate or N-monosubstituted hydrazines) to the new derivatives of pyrazolo[3,4-c]pyridazine [IXa-d]. The structures of the novel compounds were confirmed by elemental and spectral analyses. The effect of several synthesized derivatives on the central nervous system was studied.

Reactions of per-O-acetylglucosyl isothiocyanate with carbon bases. A new method for the stereocontrolled syntheses of nucleosides and glucosylaminothiophenes

Reaction of 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate 5 with diethyl malonate in a basic medium gave the corresponding glucopyranosyl thioamide without significant deacetylation. This thioamide in solution presents Z-anti as the sole configuration. Reactions of 5 with carbanions which have an ethoxycarbonyl group are a way to prepare anomerically pure N- nucleoside derivatives of pyrrole and tetrahydropyridine. Reactions of 5 with carbanions stabilized by one cyano group are used to prepare glucosylamino thiophenes with only the β-configuration. Some other stereochemical aspects of the prepared compounds are discussed.