15898-37-0

Basic information

• Product Name: o-Toluenesulfinic acid, sodium salt
• Synonyms: o-Toluenesulfinic acid, sodium salt;Sodium o-toluenesulfinate;sodium:2-methylbenzenesulfinate
• CAS NO: 15898-37-0
• Molecular Formula: C₇H₇O₂S*Na
• Molecular Weight: 178.18405
• Mol File: 15898-37-0.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: o-Toluenesulfinic acid, sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: o-Toluenesulfinic acid, sodium salt(15898-37-0)
• EPA Substance Registry System: o-Toluenesulfinic acid, sodium salt(15898-37-0)

Safety Data

• Hazardous Substances Data: 15898-37-0(Hazardous Substances Data)

Upstream product

• 16419-60-6 2-Methylphenylboronic acid 
• 63369-67-5 2-methylbenzenesulfinyl chloride 
• 137-06-4 2-thiocresol 
• 133-59-5 Toluene-2-sulfonyl chloride 

Downstream Products

• 243661-09-8 2-(2-methylbenzenesulfonyl)acetonitrile 
• 68276-70-0 1-(allylsulfonyl)-2-methylbenzene 
• 1137486-72-6 1,3,7-trimethyl-8-(o-tolyl)-xanthine 
• 163977-61-5 butyl (2E)-3-(2-methylphenyl)acrylate 
• 577-16-2 2-Methylacetophenone 
• 131-58-8 2-Methylbenzophenone 
• 2040-14-4 2-methylpropiophenone 
• 1158514-20-5 1-(o-tolylsulfonyl)piperidine 
• 643-58-3 2-methylbiphenyl 
• 163883-28-1 1-phenyl-2-(o-tolylsulfonyl)ethan-1-one 
• 67448-06-0 N,N,2-trimethylbenzenesulfonamide 
• 1381847-77-3 1-methyl-2-(o-tolylthio)-1H-pyrrole 
• 63641-17-8 1-methyl-2-((trifluoromethyl)sulfonyl)benzene 
• 65246-39-1 2-(2-methylphenyl)benzo[b]furan 

Relevant articles and documents

Sulfonylation of Aryl Halides by Visible Light/Copper Catalysis

An efficient visible-light-assisted, copper-catalyzed sulfonylation of aryl halides with sulfinates is reported. In our protocol, a single ligand CuI photocatalyst formed in situ was used in the photocatalytic transformation. Diverse organosulfones were obtained in moderate to good yields. This strategy demonstrates a promising approach toward the synthesis of diverse and useful organosulfones.

Copper catalysed oxidative α-sulfonylation of branched aldehydes using the acid enhanced reactivity of manganese(iv) oxide

The oxidative coupling of secondary aldehydes and sulfinate salts is achieved using copper catalysis to form α-sulfonyl aldehydes. The use of an acidic co-solvent is important to adjust the oxidation potential of MnO2 as an oxidant. A broad range of sulfonylated aldehydes is prepared, and their further functionalisation is demonstrated. A dual ionic/radical pathway mechanism is proposed.

Copper-Catalyzed Enantioselective Construction of Tertiary Propargylic Sulfones

Tertiary propargylic sulfones are of significant importance in organic synthesis and medicinal chemistry, but to date no general asymmetric synthesis approach has been developed. We disclose a versatile copper-catalyzed sulfonylation of propargylic cyclic carbonates using sodium sulfinates that allows the construction of propargylic sulfones featuring elusive quaternary stereocenters. This method provides the first successful example of such an enantioselective propargylic sulfonylation, features high asymmetric induction, wide functional group tolerance, and scalability, and enables attractive product diversification.