15901-51-6

Basic information

• Product Name: ethyl 3-methylisothiazole-4-carboxylate
• Synonyms: ethyl 3-Methyl-1,2-thiazole-4-carboxylate;Ethyl 3-methyl-1,2-thiazole-4-carboxylate, 4-(Ethoxycarbonyl)-3-methyl-1,2-thiazole;ethyl 3-methyl-1,2-thiazole-4-carboxylate, 3-methyl-isothiazole-4-carboxylic acid ethyl ester, 3-Methyl-isothiazol-carbonsaeure-(4)-aethylester, 3-Methyl-4-isothiazolcarbonsaeureaethylester, Ethyl-3-methyl-4-isothiazolcarboxylat
• CAS NO: 15901-51-6
• Molecular Formula: C7H9NO2S
• Molecular Weight: 171.219
• Mol File: 15901-51-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 102-103 °C(Press: 8 Torr)
• Appearance: /
• Density: 1.198±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.72±0.22(Predicted)
• CAS DataBase Reference: ethyl 3-methylisothiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-methylisothiazole-4-carboxylate(15901-51-6)
• EPA Substance Registry System: ethyl 3-methylisothiazole-4-carboxylate(15901-51-6)

Safety Data

• Hazardous Substances Data: 15901-51-6(Hazardous Substances Data)

Usage

General Description

Ethyl 3-methylisothiazole-4-carboxylate is a chemical compound that belongs to the family of isothiazole derivatives. It is commonly used as a fragrance ingredient in various personal care products and household goods. It has a strong, fruity odor with citrus and tropical fruit notes, and is often used to impart a fresh and clean scent to products such as soaps, shampoos, and detergents. ethyl 3-methylisothiazole-4-carboxylate is also used as a flavoring agent in food and beverages, adding a sweet, fruity flavor. Additionally, it has antimicrobial properties, which make it useful in preserving and extending the shelf life of consumer products. Overall, ethyl 3-methylisothiazole-4-carboxylate is a versatile chemical with applications in fragrance, flavor, and preservation industries.

Upstream product

• 626-34-6 ethyl aminocrotonate 
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• 41867-20-3 ethyl (E)-3-aminobut-2-enoate 
• 876191-55-8 ethyl 3-amino-2-methanethioylbut-2-enoate 
• 92498-49-2 1-(3-methyl-isothiazole-4-carbonyl)-1,2-dihydro-quinoline-2-carbonitrile 
• 15903-66-9 3-methyl-isothiazole-4-carboxylic acid 
• 17265-59-7 3-methyl-isothiazole-4-carbaldehyde 
• 64-17-5 ethanol 
• 10284-34-1 3-methyl-isothiazole-4-carbonyl chloride 
• 58850-81-0 3‐methyl‐1,2‐thiazole‐4‐carbonitrile 

Downstream Products

• 15903-66-9 3-methyl-isothiazole-4-carboxylic acid 

Relevant articles and documents

Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2] thiazolo[5,4- d ]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent

Structure-activity relationship analysis identified (+)-N-(3-aminopropyl)- N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl) -2-methylpropyl]-4-methylbenzamide (AZD4877), from a series of novel kinesin spindle protein (KSP) inhibitors, as exhibiting both excellent biochemical potency and pharmaceutical properties suitable for clinical development. The selected compound arrested cells in mitosis leading to the formation of the monopolar spindle phenotype characteristic of KSP inhibition and induction of cellular death. A favorable pharmacokinetic profile and notable in vivo efficacy supported the selection of this compound as a clinical candidate for the treatment of cancer.