159015-71-1Relevant academic research and scientific papers
Efficient and selective palladium-catalyzed direct oxidative esterification of benzylic alcohols under aerobic conditions
Hu, Yongke,Li, Bindong
, p. 7301 - 7307 (2017/11/29)
A highly efficient palladium-catalyzed approach for the direct oxidative esterification of benzylic alcohols with methanol and long-chain aliphatic alcohols under mild conditions has been achieved. This practical catalyst system exhibits a broad substrate scope and good functional group tolerance. Catalytic amount of Bi(OTf)3 is used as co-catalyst to improve the activity and selectivity of the reactions. A variety of esters are obtained in yields of 43–96%.
Alkylation Reactions of 2-Methylpropyl 3-(2-Methylpropoxy)-5-oxocyclohex-3-ene-1-carboxylate
Mokbel, Luci,Savage, G. Paul,Simpson, Gregory W.
, p. 1727 - 1734 (2007/10/02)
The anion derived from 2-methylpropyl 3-(2-methylpropoxy)-5-oxocyclohex-3-ene-1-carboxylate was reacted with methyl iodide to give cis and trans isomers of 2-methylpropyl 6-methyl-3-(2-methylpropoxy)-5-oxocyclohex-3-ene-1-carboxylate.The reaction proceeded with high regioselectivity.A combination of n.m.r. experiments was used to determine that the major diastereomer was in a trans configuration.The dianion derived from 2-methylpropyl 3-(2-methylpropoxy)-5-oxocyclohex-3-ene-1-carboxylate methylated at C1 and C6 with a roughly equal proportion of cis and trans isomers.When treated with 1 equiv. of 1-bromo-3-chloropropane the same dianion alkylates at C1 to give 2-methylpropyl 1-(3-chloropropyl)-3-(2-methylpropoxy)-5-oxocyclohex-3-ene-1-carboxylate.
