159015-69-7

Upstream product

• 78-83-1 2-methyl-propan-1-ol 
• 60891-20-5 2-methylpropyl 3-(2-methylpropoxy)-5-oxocyclohex-3-ene-1-carboxylate 
• 109-70-6 1.3-chlorobromopropane 
• 159015-71-1 2-methylpropyl 3,5-dimethoxybenzoate 
• 42858-60-6 3,5-cyclohexanedione-1-carboxylic acid 

Relevant academic research and scientific papers

Alkylation Reactions of 2-Methylpropyl 3-(2-Methylpropoxy)-5-oxocyclohex-3-ene-1-carboxylate

The anion derived from 2-methylpropyl 3-(2-methylpropoxy)-5-oxocyclohex-3-ene-1-carboxylate was reacted with methyl iodide to give cis and trans isomers of 2-methylpropyl 6-methyl-3-(2-methylpropoxy)-5-oxocyclohex-3-ene-1-carboxylate.The reaction proceeded with high regioselectivity.A combination of n.m.r. experiments was used to determine that the major diastereomer was in a trans configuration.The dianion derived from 2-methylpropyl 3-(2-methylpropoxy)-5-oxocyclohex-3-ene-1-carboxylate methylated at C1 and C6 with a roughly equal proportion of cis and trans isomers.When treated with 1 equiv. of 1-bromo-3-chloropropane the same dianion alkylates at C1 to give 2-methylpropyl 1-(3-chloropropyl)-3-(2-methylpropoxy)-5-oxocyclohex-3-ene-1-carboxylate.