159029-33-1

Basic information

• Product Name: Methyl 3-aMino-2-(aMinoMethyl)propanoate
• Synonyms: Methyl 3-aMino-2-(aMinoMethyl)propanoate;Methyl 3-amino-2-(aminomethyl)
• CAS NO: 159029-33-1
• Molecular Formula: C₅H₁₂N₂O₂
• Molecular Weight: 132.16098
• Mol File: 159029-33-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 225.2±30.0 °C(Predicted)
• Appearance: /
• Density: 1.080±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.47±0.10(Predicted)
• CAS DataBase Reference: Methyl 3-aMino-2-(aMinoMethyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-aMino-2-(aMinoMethyl)propanoate(159029-33-1)
• EPA Substance Registry System: Methyl 3-aMino-2-(aMinoMethyl)propanoate(159029-33-1)

Safety Data

• Hazardous Substances Data: 159029-33-1(Hazardous Substances Data)

Usage

General Description

Methyl 3-amino-2-(aminomethyl)propanoate is a compound with the chemical formula CH3NHCH2CH(NH2)COOCH3. It is an amino acid derivative, and its primary function is to act as a starting material for the synthesis of other organic compounds, particularly in the pharmaceutical industry. It is often used as a building block for the preparation of various drug molecules. It is also known for its role in the formation of peptide bonds and is commonly used in peptide synthesis. Additionally, it has been found to have potential applications in the development of new therapeutic agents and drugs.

Upstream product

• 22262-60-8 methyl 3-bromo-2-(bromomethyl)propionate 
• 159029-60-4 methyl 3-azido-2-(azidomethyl)propionate 
• 159029-61-5 methyl 3-((tert-butoxycarbonyl)amino)-2-(((tert-butoxycarbonyl)amino)methyl)propanoate 

Downstream Products

• 960389-33-7 methyl 8-(3-bromophenyl)-8-(4-methoxyphenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidine-3-carboxylate 

Relevant articles and documents

Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors

We report the synthesis of a series of monoanionic phosphotyrosyl (pTyr) mimetic-containing tripeptides based on 'Fmoc-Glu(OBn)-Xxx-Leu-amide' (where Xxx = pTyr mimetic) and their N-terminally modified derivatives. The inhibitory potencies of compounds were tested against YopH and human PTP1B enzymes. Several compounds exhibited noteworthy activity against both YopH and PTP1B. Among the N-terminally modified analogues, 5-methylindole derivative 30 was found to be the best moiety to replace base-labile Fmoc group. A mode of binding with YopH is proposed for tripeptides 21, 30, and 31.

An Efficient Synthesis of Some 6-Substituted 4,8-Diaza-3,3,9,9-tetramethylundeca-2,10-dione Dioximes (Propylene Amine Oximes, PnAOs): Ligands for 99mTc Complexes Used in Structure Distribution Relationship (SDR) Studies

Technetium complexes of the ligand PnAO are of interest as commercial radiopharmaceuticals.In general, PnAOs are synthesized by alkylation of a propylenediamine derivative with 3-chloro-3-methyl-2-nitrosobutane (2).This alkylation reaction proved to be low yielding.With modestly bulky substituents at the 2-position of 1,3-diaminopropane, little or none of the required PnAO was obtained.As a result, an alternative approach of the synthesis of PnAO was developed.This method involved the alkylation of the propylenediamine with 3-bromo-3-methylbutan-2-one (18) followed by oximation of the resulting diamine-diketone (19).By this method, PnAOs were prepared in good yield, even with bulky C-2 substituents.Fourteen PnAO derivatives were prepareed by this method.We also describe the syntheses of several new propylenediamine dervatives.