1590366-84-9

Upstream product

• 1131-33-5 2-phenylpyridin N-oxide 
• 5572-94-1 5,5-dimethyl-2-(4-iodophenyl)-1,3,2-dioxaborinane 
• 544-13-8 Glutaronitrile 
• 5122-99-6 4-iodophenylboronic acid 
• 98-80-6 phenylboronic acid 
• 898767-84-5 5-(4-iodophenyl)-5-oxopentanenitrile 
• 10413-00-0 5-oxo-5-phenylpentanenitrile 

Relevant academic research and scientific papers

Palladium-Catalyzed Cascade Reactions of I-Ketonitriles with Arylboronic Acids: Synthesis of Pyridines

This study presents the first example of the Pd-catalyzed cascade reactions of 5-oxohexanenitrile with arylboronic acids, affording important synthon 2-methylpyridines that can be further translated through C(sp3)-H functionalization to construct pyridine derivatives. Furthermore, this chemistry allows 5-oxo-5-Arylpentanenitrile to react with arylboronic acids to provide unsymmetrical 2,6-diarylpyridines. This protocol paves the way for the practical and atom economical syntheses of valuable pyridines with broad functional groups in moderate to excellent yields under mild conditions.

Diarylpyridine substance and 2,6- preparation method thereof (by machine translation)

The method disclosed by the invention is 2,6 - characterized in that the; reaction time of the, reaction 5 - of the palladium catalyst and the acid promoter is 12 - 24 that the reaction time of the reaction process. of the; palladium catalyst and the (acid promoter is, that) the (reaction time of the) reaction process ; of the palladium catalyst and the; acid promoter is 80 - 100 °C, the reaction time of, the reaction, 96%, 2,6 . (by machine translation)

Copper-catalyzed direct C-H arylation of pyridine N-oxides with arylboronic esters: One-pot synthesis of 2-arylpyridines

The first example of the copper-catalyzed direct C-H arylation of pyridine N-oxides with arylboronic esters has been developed, leading to a wide range of 2-arylpyridines in a one-pot synthesis with moderate to good yields without an additional reductant. This transformation allows for rapid access to a variety of 2-arylpyridines using an inexpensive catalytic system that would be more difficult to access with traditional methods. Thus, this method represents a simple and practical procedure to access 2-arylpyridines.