1590459-95-2

Upstream product

• 1590459-82-7 6-chloro-N-methyl-5-(2-phenylethynyl)pyrimidin-4-amine 
• 1590459-81-6 6-chloro-5-iodo-N-methylpyrimidin-4-amine 
• 1590459-88-3 7-methyl-6-phenyl-4-(2-tolyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 65766-32-7 6-chloro-N-methylpyrimidin-4-amine 
• 1590459-85-0 4-chloro-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 1590460-08-4 5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-(2-tolyl)-7H-pyrrolo-[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Microwave-assisted synthesis of substituted pyrrolo[2,3-d]pyrimidines

A new synthetic route to triaryl pyrrolo[2,3-d]pyrimidines from common 4,6-dichloropyrimidine has been developed. The triarylated compounds are synthesized by three cross-coupling reactions using three different catalysts. The introduction of a C-6 aryl group was achieved in a two-step process under Sonogashira conditions [Pd(dba)2/CuI] followed by intramolecular cyclization, and application of Suzuki-Miyaura conditions [Pd(PPh 3)4; PdCl2(PPh3)2] led to C-4 and C-5 diarylation. This sequence allows a flexible synthetic approach to highly arylated pyrrolopyrimidines containing different aryl groups. A new synthetic route to triaryl pyrrolo[2,3-d]pyrimidines from common 4,6-dichloropyrimidine has been developed. The triarylated compounds are synthesized by three cross-coupling reactions using three different catalysts. Copyright

Microwave-Assisted Synthesis of Substituted Pyrrolo[2,3-d]pyrimidines

A new synthetic route to triaryl pyrrolo[2,3-d]pyrimidines from common 4,6-dichloropyrimidine has been developed. The triarylated compounds are synthesized by three cross-coupling reactions using three different catalysts. The introduction of a C-6 aryl group was achieved in a two-step process under Sonogashira conditions [Pd(dba)2/CuI] followed by intramolecular cyclization, and application of Suzuki-Miyaura conditions [Pd(PPh3)4; PdCl2(PPh3)2] led to C-4 and C-5 diarylation. This sequence allows a flexible synthetic approach to highly arylated pyrrolopyrimidines containing different aryl groups.