159084-46-5Relevant academic research and scientific papers
NMR study of the tautomeric behavior of N -(α-Aminoalkyl)tetrazoles
Katritzky, Alan R.,El-Gendy, Bahaa El-Dien M.,Draghici, Bogdan,Hall, C. Dennis,Steel, Peter J.
experimental part, p. 6468 - 6476 (2010/12/24)
N-(α-Aminoalkyl)tetrazoles exist in solution as equilibrium mixtures of N1 and N2 tautomers. The position of equilibrium depends significantly on the polarity of the solvent and the substituents in the tetrazole ring. Interconversion between individual tautomers is shown to proceed via tight ion-pair intermediates in which intramolecular recombination is faster than the intermolecular crossover since the latter probably requires solvent separation of ion-pair intermediates.
A Convenient Method of Synthesis of n-Hydroxymethyl Derivatives of 5-Substituted Tetrazoles and Their Reactions with Nucleophiles
Rusinov,Ishmetova,Chupakhin
, p. 524 - 531 (2007/10/03)
A new method of synthesis of 1(2)-N-hydroxymethyl-5-aryl(hetaryl)tetrazoles, produced by reaction of 5-substituted tetrazoles with paraform in acetic acid, is described. The compounds obtained react with primary and secondary aliphatic amines, as well as with 2,6-dimethylphenol and 4-bromoacetophenone, resulting on 1,5- and 2,5-disubstituted tetrazoles, which, alternatively, can be synthesized by the Mannich reaction from 5-aryl(hetaryl)tetrazoles.
AMINOMETHYLATION OF 5-SUBSTITUTED TETRAZOLES
Binda, M.,Dziklinska, A.,Hachiam, A.F.H.,Plenkiewicz, J.
, p. 1257 - 1261 (2007/10/02)
The Mannich reaction of 5-substituted tetrazoles with formaldehyde and secondary amines was described.Some of the synthesized 2-(N,N-dialkyl-aminomethyl)-5-substituted tetrazoles on treatment with aliphatic ketones gave the corresponding 3-(5-substituted tetrazolyl-2)-1 ones in moderate yields.
