159088-33-2

Upstream product

• 100868-46-0 3,5-dichloro-4-picoline 
• 67387-76-2 3-cyclopentyloxy-4-methoxybenzylaldehyde 

Downstream Products

• 159782-41-9 1-(3-cyclopentyloxy-4-methoxy-phenyl)-2-(3,5-dichloro-pyridin-4-yl)-ethanone 

Relevant academic research and scientific papers

"Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors"

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing t

COMPOUNDS CONTAINING PHENYL LINKED TO ARYL OR HETEROARYL BY AN ALIPHATIC- OR HETEROATOM-CONTAINING LINKING GROUP

This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase

TRISUBSTITUTED PHENYL DERIVATIVES

Compounds of general formula (1) CR3)(R6)CH(R4)(z-R5) are described wherein Y is a halogen atom or a group -OR1,where R1 is an optionally substituted alkyl group;X is -O-,-S- or -N(R7)-,where R7 is a hydrogen atom or an alkyl group; R2 is an optionally substituted cycloalkyl or cycloalkenyl group;R3 and R4 which may be the same or different,is each a hydrogen atom or an alkyl.-CO2R8 (where R8 is a hydrogen atom or an alkyl,aryl,oraralkyl group),-CONR9R10 (where R9 and RI10 which may be the same or different is each a hydrogen atom or an alkyl,aryl or aralkyl group), -CSNR*R10,-cN,-CH2CN group;Z is -(CH2)n- (where n is zero or an integer 1, 2or 3; R5 is an optionally substituted monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen,sulphur or nitrogen atoms;R6 is a hydrogen atom or a hydroxyl group;and the salts, solvates,hydrates,prodrugs and N-oxides thereof. Compounds according to the invention are potent and selective phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of diseases such as asthma where an unwanted inflammatory response or muscular spasm is present

Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group

This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.