159109-14-5 Usage
Description
3-amino-4-(1H-indol-3-yl)-1H-Pyrrole-2,5-dione, also known as CPI-613, is a novel cancer-targeting agent that belongs to the class of alpha-lipoic acid analogs and functions as a lipoate mimetic compound. It has shown promising results in preclinical and clinical studies for its potential as a therapeutic agent in various solid and hematological malignancies.
Used in Pharmaceutical Industry:
3-amino-4-(1H-indol-3-yl)-1H-Pyrrole-2,5-dione is used as an anticancer agent for its ability to target the mitochondrial tricarboxylic acid cycle, disrupt energy metabolism, and induce oxidative stress in cancer cells, leading to apoptosis. It has demonstrated potential in treating a variety of solid and hematological malignancies, including pancreatic cancer, lymphoma, and leukemia.
Used in Combination Cancer Therapy:
3-amino-4-(1H-indol-3-yl)-1H-Pyrrole-2,5-dione is used to enhance the efficacy of other cancer treatments, such as chemotherapy and radiation therapy, by showing synergistic effects that improve treatment outcomes and overcome resistance in cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 159109-14-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,1,0 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 159109-14:
(8*1)+(7*5)+(6*9)+(5*1)+(4*0)+(3*9)+(2*1)+(1*4)=135
135 % 10 = 5
So 159109-14-5 is a valid CAS Registry Number.
159109-14-5Relevant articles and documents
Novel method and compounds
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Page/Page column 20; 50, (2010/02/05)
A method for the treatment of conditions associated with a need for inhibition of GSK-3, such as diabetes, dementias such as Alzheimer's disease and manic depression which method comprises the administration of a pharmaceutically effective, non-toxic amou
