159111-92-9

Upstream product

• 162779-49-9 (S)-2-(Acryloyl-benzyl-amino)-4,4-dimethoxy-butyric acid methyl ester 
• 159111-91-8 (E)-(S)-2-(Acryloyl-benzyl-amino)-6-oxo-hept-4-enoic acid methyl ester 
• 159111-90-7 (S)-2-(Acryloyl-benzyl-amino)-4-oxo-butyric acid methyl ester 

Relevant academic research and scientific papers

PROCESS AND INTERMEDIATES FOR THE PREPARATION OF EXCITATORY AMINOACID RECEPTOR ANTAGONISTS

The present invention provides novel intermediates which are useful for the preparation of excitatory amino acid receptor antagonists. Further provided is a process to enatioselectively prepare hydroisoquinoline compounds with central nervous system activ

Intramolecular Diels-Alder Route To 6-octadecahydroisoquinoline-3-Carboxylates: Intermediates For The Synthesis Of Conformationally Constrained Excitatory Amino Acid Antagonists

We report the preparation of a hydroisoquinoline intermediate potentially useful for the synthesis of some excitatory amino acid antagonists.The requisite stereochemistry is established by an intramolecular Diels-Alder reaction, and the absolute stereochemistry is ultimately derived from S-aspartic acid.Also reported is an efficient synthesis of methyl N-CBZ asparate β-aldehyde.