162779-49-9

Upstream product

• 4668-42-2 (S)-2-benzyloxycarbonylamino-succinic acid 1-methyl ester 
• 60684-59-5 methyl (S)-2-(((benzyloxy)carbonyl)amino)-4-oxobutanoate 
• 159111-87-2 methyl 2S-N-carbobenzoxy-2-amino-4,4-dimethoxybutanoate 
• 153413-52-6 (S)-2-benzyloxycarbonylamino-3-chlorocarbonyl-propionic acid methyl ester 
• 814-68-6 acryloyl chloride 
• 159111-88-3 methyl 2S-2-amino-4,4-dimethoxybutanoate 

Downstream Products

• 159111-92-9 methyl 3S,4AS,8AR-N-benzyl-1,6-dioxo-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate 
• 159111-91-8 (E)-(S)-2-(Acryloyl-benzyl-amino)-6-oxo-hept-4-enoic acid methyl ester 
• 159111-90-7 (S)-2-(Acryloyl-benzyl-amino)-4-oxo-butyric acid methyl ester 

Relevant academic research and scientific papers

Intramolecular Diels-Alder Route To 6-octadecahydroisoquinoline-3-Carboxylates: Intermediates For The Synthesis Of Conformationally Constrained Excitatory Amino Acid Antagonists

We report the preparation of a hydroisoquinoline intermediate potentially useful for the synthesis of some excitatory amino acid antagonists.The requisite stereochemistry is established by an intramolecular Diels-Alder reaction, and the absolute stereochemistry is ultimately derived from S-aspartic acid.Also reported is an efficient synthesis of methyl N-CBZ asparate β-aldehyde.