15912-88-6

Basic information

• Product Name: 8-methylpsoralen
• Synonyms: 8-methylpsoralen
• CAS NO: 15912-88-6
• Molecular Formula: C12H8 O3
• Molecular Weight: 200.19
• Mol File: 15912-88-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 150-151 °C
• Boiling Point: 369.8°Cat760mmHg
• Flash Point: 177.5°C
• Appearance: /
• Density: 1.332g/cm³
• Vapor Pressure: 1.16E-05mmHg at 25°C
• Refractive Index: 1.648
• CAS DataBase Reference: 8-methylpsoralen(CAS DataBase Reference)
• NIST Chemistry Reference: 8-methylpsoralen(15912-88-6)
• EPA Substance Registry System: 8-methylpsoralen(15912-88-6)

Safety Data

• Hazardous Substances Data: 15912-88-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H8O3/c1-7-11-9(4-5-14-11)6-8-2-3-10(13)15-12(7)8/h2-6H,1H3

Upstream product

• 4046-75-7 6-allyl-8-methylumbelliferone 
• 84660-75-3 7-allyloxy-8-methylcoumarin 
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• 2732-17-4 7-hydroxy-8-methyl-2H-chromen-2-one 
• 189831-86-5 9-Methyl-2-trimethylsilanyl-furo[3,2-g]chromen-7-one 
• 82678-22-6 4',5'-dihydro-5'-hydroxy-8-methylpsoralen 

Relevant articles and documents

A new synthesis of and methylpsoralen utilizing a palladium-copper catalyzed reaction to generate the furan ring and thus allowing for the generation of novel analogs in the 5'-position

A rapid synthesis of 1-methylpsoralen is reported that utilizes a palladium-copper catalyzed reaction to generate the furan ring. Since 8-methylpsoralen is considered one of the most photodynamic methylpsoralens known and given the fact that psoralens in general have been shown to have medicinal value against bacteria and viruses, this synthesis allows for the availability to generate new derivatives by supplying a handle in the 5'-position.

8-Aminoalkylpsoralens

The invention relates to 8-aminoalkylpsoralens, having essentially no erythematic photosensitizing activity but at the same time having substantial DNA-binding photosensitizing activity, making them of especial interest from the standpoint of suntanning and psoriasis treatment, characteristics which are unpredictable when the compounds are compared with psoralens of similar but different structure.