159141-33-0

Usage

Uses

Used in Pharmaceutical Synthesis:
(S)-2-((R)-2-CHLOROPROPANAMIDO)-4-CARBAMOYLBUTANOIC ACID is used as an intermediate for the synthesis of pharmaceutical compounds due to its ability to act as a building block for more complex molecules. Its unique structure and properties make it an essential component in the development of new drugs.
Used in Organic Chemistry Research:
In the field of organic chemistry, (S)-2-((R)-2-CHLOROPROPANAMIDO)-4-CARBAMOYLBUTANOIC ACID is used as a starting material for the synthesis of various compounds. Its chiral nature allows researchers to explore stereochemistry and asymmetric synthesis, further expanding the understanding and applications of (S)-2-((R)-2-CHLOROPROPANAMIDO)-4-CARBAMOYLBUTANOIC ACID.
Used in Drug Development:
(S)-2-((R)-2-CHLOROPROPANAMIDO)-4-CARBAMOYLBUTANOIC ACID has potential applications in drug development, where it serves as a key component in the creation of new pharmaceuticals. Its versatility and unique properties make it a valuable asset in the design and synthesis of innovative drug molecules.
Used in Medical Research:
In medical research, (S)-2-((R)-2-CHLOROPROPANAMIDO)-4-CARBAMOYLBUTANOIC ACID is utilized for its potential applications in the development of new therapeutic agents. Its unique structure and chiral nature provide researchers with opportunities to explore its properties and potential uses in treating various medical conditions.

Upstream product

• 70110-25-7 (R)-(-)-2-chloropropionyl chloride 
• 56-85-9 L-glutamine 

Downstream Products

• 39537-23-0 alanylglutamine 
• 39537-23-0 alanyl-glutamine 

Relevant academic research and scientific papers

Process research and development of L-alanyl-L-glutamine, a component of parenteral nutrition

A large-scale manufacturing method of L-alanyl-L-glutamine used for a component of parenteral nutrition has been studied. The method consisted of a reaction of D-2-chloro- or D-2-bromopropionic acid with thionyl chloride and Schotten-Baumann reaction with L-glutamine followed by ammonolysis reaction. The intermediate D-2-chloropropionyl-L-glutamine was found to be more stable than its bromo analogue. In the ammonolysis reaction, the former intermediate needed a higher reaction temperature, but the by-products produced had little effect on the quality of the final product. The structures of the by-products were conjectured mainly by mass spectrometry and they were removed by anion resin treatment and recrystallization.

Production process of chloropropionyl glutamine

The invention relates to the technical field of chemical engineering, and discloses a production process of chloropropionyl glutamine. The production process comprises following steps: carrying out acylating chlorination reaction: adopting D-2-chloropropionic acid and thionyl chloride as raw materials, adopting DMF (N, N-dimethylformamide) as a catalyst, and carrying out reaction to generate D-2-chloropropionyl chloride, sulfur dioxide and hydrogen chloride. According to the production process of chloropropionyl glutamine, 791kg of thionyl chloride is pressed into a dry and clean 2000 L enamelreaction kettle by using nitrogen, stirring is started, and 0.75kg of N, N-dimethylformamide is slowly dropwise added; then, 600kg of D-2-chloropropionic acid is pressed into a dry and clean 1000L enamel high-level tank by using nitrogen gas, a reaction kettle jacket is subjected to 75 DEG C hot water bath to increase the temperature of the system to 60-65 DEG C, D-2-chloropropionic acid is dropwise added into the reaction kettle for about 4 h at 60 to 65 DEG C, and the gas release amount is controlled by adjusting the dropwise adding speed. T production process is simple in steps, complete in reactant reaction, high in raw material utilization rate and low in preparation cost, troubles of users are avoided, and the production process is convenient for users to use.

Recovery of ammonia in the dipeptide manufacturing processes

An example of an improvement in recovering ammonia in a dipeptide manufacturing process is described. The synthetic method, which makes use of the ammonolysis reaction, has been studied and found to produce dipeptides of satisfactory quality in high yield on a large scale. However, the treatment of unreacted ammonia in the ammonolysis reaction caused a reduction in the productivity and increased the production cost during actual manufacture. Therefore, a method to recover the unreacted ammonia has been investigated through simulations and trial runs using model solutions. Consequently, the modified process provided an improvement in the productivity and cost savings. In addition, the recovered ammonia could possibly be used for recycling. It was verified in a lab experiment that the reused ammonia did not lower the quality of the dipeptide.