159143-76-7Relevant academic research and scientific papers
Estradiol conjugates and uses thereof
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Page/Page column 12; 14, (2010/11/08)
A conjugated prodrug of an estradiol compound conjugated to a biological activity modifying agent.
Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site
Cushman,He,Katzenellenbogen,Lin,Hamel
, p. 2041 - 2049 (2007/10/02)
In order to define the structural parameters associated with the antitubulin activity and cytotoxicity of 2-methoxyestradiol, a mammalian metabolite of estradiol, an array of analogs was synthesized and evaluated. The potencies of the new congeners as inh
