159149-49-2

Upstream product

• 331665-89-5 N-benzyl-3,3-diphenylpropionamide 
• 37089-77-3 3,3-diphenylpropanoyl chloride 
• 606-83-7 3,3-Diphenylpropionic acid 
• 5586-73-2 3-diphenylpropyl amine 
• 100-39-0 benzyl bromide 
• 530-48-3 1,1-Diphenylethylene 
• 201230-82-2 carbon monoxide 
• 100-46-9 benzylamine 
• 100-52-7 benzaldehyde 
• 29648-95-1 1-chloro-3,3-diphenylpropane 

Downstream Products

• 1101172-09-1 3-[3-benzyl-3-(3,3-diphenyl-propyl)-ureido]-benzoic acid methyl ester 

Relevant academic research and scientific papers

FENDILINE DERIVATIVES AND METHODS OF USE THEREOF

Disclosed herein are novel derivatives of fendiline, including compounds of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising these derivative compounds. Methods and intermediates useful for making the derivatives, and methods of using the derivatives, for example, for the inhibition of K-Ras plasma membrane localization, and compositions thereof, including for the treatment of cancer, are also provided.

New potent calcimimetics: I. Discovery of a series of novel trisubstituted ureas

Starting from Fendiline and R-568, we identified a novel series of urea compounds as positive allosteric modulators of the calcium sensing receptor (CaSR), as part of a program to identify novel therapeutics for secondary hyperparathyroidism. Initially id

Cascade synthesis of fenpiprane and related pharmaceuticals via rhodium-catalyzed hydroaminomethylation

A novel rhodium catalytic system with Naphos as ligand was developed for an efficient hydroaminomethylation of 1,1-diphenylethene under relatively mild conditions. This will allow for an atom-economic and environmentally benign synthesis of fenpiprane and related pharmaceuticals.

DERIVATlVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE AND USES THEREFOR

The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes

Synthesis, cytotoxicity, and DNA-topoisomerase inhibitory activity of new asymmetric ureas and thioureas

A new series of N-3,3-diphenylpropyl-N-(p-X-benzyl)-N′-phenylureas (5a-g) and thioureas (6a-g) were synthesized by the reaction of secondary amines and phenyl isocyanate or isothiocyanate. The cytotoxic effects of the urea and thiourea derivatives were ev

INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

The present invention comprises low molecular weight peptidyl compounds that inhibit the farnesyl-protein transferase. Furthermore, these compounds differ from the mono- or dipeptidyl analogs previously described as inhibitors of farnesyl-protein transferase in that they do not have a thiol moiety. The lack of the thiol offers unique advantages in terms of improved pharmacokinetic behavior in animals, prevention of thiol-dependent chemical reactions, such as rapid autoxidation and disulfide formation with endogenous thiols, and reduced systemic toxicity. Further contained in this invention are chemotherapeutic compositions containing these farnesyl transferase inhibitors and methods for their production