159187-00-5Relevant academic research and scientific papers
Synthesis and Antimicrobial Activity of some New 4-Isogramines, 4-Arylthiomethyl and 4-Arylazo Derivatives of 5-Hydroxyindoles
Joshi, Raghavendra G.,Gadaginamath, Guru S.,Pujar, Basayya G.
, p. 175 - 178 (2007/10/02)
Mannich reaction of 5-hydroxyindoles (1-10) with formaldehyde and secondary amines produced the 4-isogramines (11-48).The nucleophilic displacement of dimethylamine from 4-dimethylaminomethyl-5-hydroxyindoles (11-15) was effected by heating them with thiophenols to get 4-arylthiomethyl-5-hydroxyindoles (49-58).The treatment of 5-hydroxyindoles (1-4 and 6-9) with aryldiazonium salt solution afforded exclusively 4-arylazo-5-hydroxyindoles (59-74).All the compounds were screened for their antibacterial and antifungal activities.
