1592-62-7

Basic information

• Product Name: 2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-OL
• Synonyms: Carbazol-1-ol,1,2,3,4-tetrahydro- (7CI)
• CAS NO: 1592-62-7
• Molecular Formula: C₁₂H₁₃NO
• Molecular Weight: 187.24
• Mol File: 1592-62-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-OL(1592-62-7)
• EPA Substance Registry System: 2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-OL(1592-62-7)

Safety Data

• Hazardous Substances Data: 1592-62-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-OL is used as a key intermediate in the synthesis of various organic compounds. Its unique structure and reactivity make it a valuable building block for the creation of new molecules with specific properties.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-OL is used as a starting material for the development of new drugs. Its potential biological activities, such as antioxidant properties and enzyme inhibition, make it a promising candidate for the treatment of various diseases and conditions.
Used in Research Applications:
2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-OL is utilized in research settings to study its therapeutic properties and explore its potential use in drug development. Researchers are investigating its antioxidant capabilities and enzyme inhibition to understand its potential applications in treating specific diseases and improving overall health.
Used in the Development of New Materials:
2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-OL is also being explored for its potential use in the development of new materials with unique properties. Its chemical structure and reactivity make it a candidate for creating innovative materials with applications in various industries.

Upstream product

• 3456-99-3 1-oxo-2,3,4,9-tetrahydrocarbazole 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 62-53-3 aniline 
• 1687-48-5 cyclohexane 1,2-dione monophenylhydrazone 
• 133-32-4 4-indol-3-yl-butyric acid 
• 49850-32-0 ethyl 4-(1H-indol-3-yl) butanoate 
• 942-01-8 1,2,3,4-tetrahydrocarbazole 

Downstream Products

• 882033-76-3 1-(4-chloro-phenoxy)-2,3,4,9-tetrahydro-1H-carbazole 

Relevant articles and documents

Catalytic Enantioselective Synthesis of Tetrahydocarbazoles and Exocyclic Pictet-Spengler-Type Reactions

A synthetic strategy for the synthesis of chiral tetrahydrocarbazoles (THCAs) has been developed. The strategy relies on two types of 6-exo-trig cyclization of 3-substituted indole substrates. Enantioselective domino Friedel-Crafts-type reactions leading to THCAs can be catalyzed by chiral phosphoric acid derivatives (with up to >99% ee), and the first examples of exocyclic Pictet-Spengler reactions to form THCAs are reported.

Enantioselective Synthesis of 1- and 4-Hydroxytetrahydrocarbazoles through Asymmetric Transfer Hydrogenation

Several 1- and 4-hydroxytetrahydrocarbazoles were prepared in high yields (up to 99%) and excellent enantiomeric excesses (up to >99% ee) from the corresponding 1- and 4-oxotetrahydrocarbazoles through asymmetric transfer hydrogenation by using the commercially available Noyori-Ikariya ruthenium catalyst. The immediate use of the freshly prepared catalyst and the use of a HCO 2 H-DABCO (11:6) mixture as the hydrogen source are crucial for achieving high activity and enantioselectivity. In this way, a tetrahydrocarbazole heterocycle fused to a lactone moiety was synthesized in 45% yield and 97% ee.

Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists

The SAR of a new series of tetrahydrocarbazole derivatives is described: the appropriate decoration of this template led to the identification of a new class of NPY-1 antagonists showing good in vitro potency and a promising in vivo pharmacokinetic profil