159276-65-0Relevant academic research and scientific papers
Phenylboronic Acid Appended Pyrene-Based Low-Molecular-Weight Injectable Hydrogel: Glucose-Stimulated Insulin Release
Mandal, Deep,Mandal, Subhra Kanti,Ghosh, Moumita,Das, Prasanta Kumar
, p. 12042 - 12052 (2015)
A pyrene-containing phenylboronic acid (PBA) functionalized low-molecular-weight hydrogelator was synthesized with the aim to develop glucose-sensitive insulin release. The gelator showed the solvent imbibing ability in aqueous buffer solutions of pH valu
Glucose-triggered dissolution of phenylboronic acid-functionalized cholesterol-based niosomal self-assembly for tuneable drug release
Mandal, Deep,Das, Suman
, p. 7855 - 7865 (2019)
The present study described the design and development of a new class of non-ionic vesicular self-aggregates and their utilization as glyco-responsive drug release vehicles. Cholesterol-based phenylboronic acid (PBA)-functionalized amphiphile was synthesi
Dissipation of self-assemblies by fusion of complementary gels: An elegant strategy for programmed enzymatic reactions
Mandal, Deep,Choudhury, Pritam,Sarkar, Deblina,Das, Prasanta Kumar
, p. 7844 - 7847 (2017)
Cholesterol based phenylboronic acid and glucose tailored complementary gels were developed which underwent mutual self-destruction upon mixing due to the formation of a boronate-diol adduct. This dissipation of the complementary gels was employed in a programmed enzymatic reaction and in pro-drug activation.
Building addressable libraries: Site-selective Suzuki reactions on microelectrode arrays
Hu, Libo,Maurer, Karl,Moeller, Kevin D.
, p. 1273 - 1276 (2009)
A site-selective Suzuki reaction has been developed for use on microelectrode arrays. The reaction conditions employed are similar to those used to achieve site-selective Heck reactions. The reaction can be run with either an aryliodide attached to the su
Copper-mediated radioiodination reaction through aryl boronic acid or ester precursor and its application to direct radiolabeling of a cyclic peptide
Kondo, Yuto,Kimura, Hiroyuki,Fukumoto, Chiaki,Yagi, Yusuke,Hattori, Yasunao,Kawashima, Hidekazu,Yasui, Hiroyuki
, p. 336 - 345 (2021/05/27)
A copper-mediated radioiodination using aryl boronic precursors is attracting attention as a solution to oxidative iododestannylation and nickel-mediated radioiodination drawbacks. The copper-mediated radiolabeling method allows radioiodination at room te
Assembly of pH-Responsive Antibody-Drug-Inspired Conjugates
Heck, Astrid Johanna,Kuan, Seah Ling,Ng, David Y. W.,Nuhn, Lutz,Pieszka, Michaela,Raabe, Marco,Schauenburg, Dominik,Wang, Tao,Weil, Tanja,Zegota, Maksymilian Marek,Führer, Siska
, (2021/12/08)
With the advent of chemical strategies that allow the design of smart bioconjugates, peptide- and protein-drug conjugates are emerging as highly efficient therapeutics to overcome limitations of conventional treatment, as exemplified by antibody-drug conjugates (ADCs). While targeting peptides serve similar roles as antibodies to recognize overexpressed receptors on diseased cell surfaces, peptide-drug conjugates suffer from poor stability and bioavailability due to their low molecular weights. Through a combination of a supramolecular protein-based assembly platform and a pH-responsive linker, the authors devise herein the convenient assembly of a trivalent protein-drug conjugate. The conjugate should ideally possess distinct features of ADCs such as 1) recognition sites that recognize cell receptor and are arranged on 2) distinct locations on a high molecular weight protein scaffold, 3) a stimuli-responsive linker, as well as 4) an attached payload such as a drug molecule. These AD-like conjugates target cancer cells that overexpress somatostatin receptors, can enable controlled release in the microenvironment of cancer cells through a new pH-responsive biotin linker, and exhibit stability in biological media.
CHARGE-SWITCHABLE POLYMERIC DEPOT FOR GLUCOSE-TRIGGERED INSULIN DELIVERY WITH ULTRAFAST RESPONSE
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Page/Page column 47; 48, (2019/06/11)
A composition comprising a glucose-responsive charge-switchable polymer is described. In the absence of glucose or under normoglycemic conditions, the positively charged polymer can be complexed with negatively charged therapeutic agents, such as insulin.
Xylene green FF derivative dye and synthetic method thereof
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Paragraph 0018; 0019, (2017/07/21)
The invention provides a full chemical preparation method of a xylene green FF derivative dye. The method comprises the following step of performing reactions such as chlorination by taking xylene green FF as a raw material to finally obtain the xylene green FF derivative. The invention aims to provide the xylene green FF derivative dye which is low in cost and a synthetic method thereof.
Radioactive iodine labeling method
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Paragraph 0125; 0126; 0127; 0128; 0129, (2017/07/23)
The invention discloses a radioactive iodine labeling method. Ar-B(OH)2 is allowed to react with NaI in a reaction solvent in the presence of a copper coordination compound so as to obtain Ar-I, so radioactive iodine labeling is realized. The method
A Highly Efficient Copper-Mediated Radioiodination Approach Using Aryl Boronic Acids
Zhang, Pu,Zhuang, Rongqiang,Guo, Zhide,Su, Xinhui,Chen, Xiaoyuan,Zhang, Xianzhong
supporting information, p. 16783 - 16786 (2016/11/17)
A convenient and quantitative radioiodination method by copper-mediated cross-coupling of aryl boronic acids was developed. The mild labeling conditions, ready availability of the boronic acid substrate, simple operation, broad functional group tolerance and excellent radiochemical yield (RCY) make this a practical strategy for radioiodine labeling without further purification.
