159352-65-5

Upstream product

• 108-30-5 succinic acid anhydride 
• 159352-64-4 (5Z,7E)-(1S,3R)-1,3-bis(tert-butyldimethylsiloxy)-9,10-secocholesta-5,7,10(19)-trien-11α,25-diol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 151922-32-6 cholesta-5,7-diene-1α,3β,11α,25-tetraol 
• 151922-31-5 1α,2α-epoxy-cholesta-5,7-diene-3β,11α,25-triol 
• 159352-62-2 3β-(tert-butyldimethylsiloxy)cholesta-5,7-diene-1α,11α,25-triol 
• 151922-33-7 3β-(tert-butyldimethylsiloxy)-1α,25-dihydroxycholesta-5,7-dien-11α-yl acetate 
• 151922-34-8 (5Z,7E)-(1S,3R)-3-(tert-butyldimethylsiloxy)-1,25-dihydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl acetate 
• 159352-63-3 (5Z,7E)-(1S,3R)-1,3-bis(tert-butyldimethylsiloxy)-25-hydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl acetate 
• 159352-61-1 1α,2α-epoxy-3β,11α,25-trihydroxy-4'-phenyl-3',5'-dihydro-5,8-<1,2>epi<1,2,4>triazolo-5α,8α-cholest-6-ene-3',5'-dione 

Relevant academic research and scientific papers

Syntheses of 11α-(3-Carboxypropanoyloxy)-1α,25-dihydroxyvitamin D3 and 11α-(4-Carboxybutanoyloxy)-1α,25-dihydroxyvitamin D3: Novel Haptenic Derivatives of Production of Highly Specific Antibodies to 1α,25-Dihydroxyvitamin D3

The measurement of serum/plasma levels of 1α,25-dihydroxyvitamin D3 1 a is important for the diagnosis influencing vitamin D metabolism.To obtain antibodies to the metabolite 1a which are highly specific and useful for development of immunoassays, two novel haptenic derivatives, 11α-(3-carboxypropanoyloxy)-1α,25-dihydroxyvitamin D3 2a and 11α-(4-carboxybutanoyloxy)-1α,25-dihydroxyvitamin D3 2b were synthesized each in 19 steps from a suitably protected derivative (3) of 11α,25-dihydroxycholesterol.