159435-00-4 Usage
Uses
Used in Biochemical Research:
6-IATR is used as a labeling agent for proteins in biochemical research. Its thiol reactivity allows for the specific modification of cysteine residues in proteins, enabling the study of protein structure, function, and interactions.
Used in Fluorescence Microscopy:
In fluorescence microscopy, 6-IATR is used as a fluorescent probe for visualizing proteins within cells or tissues. Its bright fluorescence and resistance to photobleaching make it an ideal choice for long-term imaging studies and the detection of protein dynamics.
Used in Drug Delivery Systems:
6-IATR can be employed in the development of drug delivery systems, particularly for targeted protein labeling and tracking. Its ability to label proteins with high specificity can be utilized to improve the efficiency and selectivity of drug delivery, potentially enhancing therapeutic outcomes.
Used in Analytical Chemistry:
In analytical chemistry, 6-IATR can be used as a detection reagent in various assays and techniques, such as high-performance liquid chromatography (HPLC) or capillary electrophoresis (CE), to identify and quantify proteins or other thiol-containing molecules.
Used in Pharmaceutical Development:
6-IATR may also be utilized in the pharmaceutical industry for the development of new drugs targeting specific proteins. Its ability to label proteins with high specificity can aid in the discovery and optimization of novel therapeutic agents.
Used in Environmental Monitoring:
6-IATR can be employed in environmental monitoring applications to detect and quantify thiol-containing pollutants or contaminants. Its high sensitivity and selectivity make it a valuable tool for assessing environmental samples and ensuring compliance with regulatory standards.
Check Digit Verification of cas no
The CAS Registry Mumber 159435-00-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,4,3 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 159435-00:
(8*1)+(7*5)+(6*9)+(5*4)+(4*3)+(3*5)+(2*0)+(1*0)=144
144 % 10 = 4
So 159435-00-4 is a valid CAS Registry Number.
159435-00-4Relevant academic research and scientific papers
Synthesis and Characterisation of Pure Isomers of Iodoacetamidotetramethylrhodamine
Corrie, John E. T.,Craik, James S.
, p. 2967 - 2974 (2007/10/02)
The isomeric benzoylnitrobenzoate esters 5 and 6, prepared by condensation of 4-nitrophthalic anhydride and 3-(dimethylamino)phenol followed by esterification, were separated by fractional crystallisation and their structures assigned by NOE difference spectroscopy.Reduction of the nitro group in each compound followed by acetylation and ester hydrolysis gave the isomeric acetamido acids 7 and 8, which were efficiently condensed with 3-(diemthylamino)phenol in the presence of trimethylsilyl polyphosphate to give the acetamidorhodamines 9 and 10, respectively.These compounds were converted by standard means into the pure 6- and 5-(iodoacetamido)tetramethylrhodamines 1 and 2.The visible spectroscopic properties of the compounds were examined and accurate extinction determined.
