159435-00-4

Basic information

• Product Name: 6-IATR
• Synonyms: 6-IodoacetaMidotetraMethyl RhodaMine, (Technical grade)
• CAS NO: 159435-00-4
• Molecular Formula: C26H24IN3O4
• Molecular Weight: 569.39093
• Product Categories: Fluorescent Labels & Indicators, Heterocycles, MTS & Sulfhydryl Active Reagents
• Mol File: 159435-00-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 769.4±60.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Mixture of Chloroform and Methanol (Slightly)
• PKA: 12.03±0.20(Predicted)
• CAS DataBase Reference: 6-IATR(CAS DataBase Reference)
• NIST Chemistry Reference: 6-IATR(159435-00-4)
• EPA Substance Registry System: 6-IATR(159435-00-4)

Safety Data

• Hazardous Substances Data: 159435-00-4(Hazardous Substances Data)

Usage

Chemical Properties

6-IodoacetaMidotetraMethyl is Purple Solid

Uses

6-IodoacetaMidotetraMethyl is a thiol reactive fluorescent probe for the labelling of proteins. Rhodamine dyes are used extensively in various aspects of fluorescence microscopy because of their brightness and resistance to photobleaching. They are valuable in studies directed at probing changes in orientation and mobility of proteins using fluorescence anisotropy measurements. It is a mixture of the 6-Iodo and 6-chloro.

Upstream product

• 159435-10-6 6-amino-3',6'-bis(dimethylamino)spiro<1,3-dihydroisobenzofuran-1,9'-xanthen>-3-one 
• 159435-06-0 6-acetamido-3',6'-bis(dimethylamino)spiro<1,3-dihydroisobenzofuran-1,9'-xanthen>-3-one 
• 159435-02-6 methyl 2-(4'-dimethylamino-2'-hydroxybenzoyl)-4-nitrobenzoate 
• 166442-37-1 4-acetamido-2-(4'-dimethylamino-2'-hydroxybenzoyl)benzoic acid 
• 1026132-88-6 4-Amino-2-(4-dimethylamino-2-hydroxy-benzoyl)-benzoic acid methyl ester 
• 610-27-5 4-nitrophthalic acid 
• 5466-84-2 4-nitrophthalic anhydride 
• 159435-08-2 6-chloroacetamido-3',6'-bis(dimethylamino)spiro<1,3-dihydroisobenzofuran-1,9'-xanthen>-3-one 

Relevant articles and documents

Synthesis and Characterisation of Pure Isomers of Iodoacetamidotetramethylrhodamine

The isomeric benzoylnitrobenzoate esters 5 and 6, prepared by condensation of 4-nitrophthalic anhydride and 3-(dimethylamino)phenol followed by esterification, were separated by fractional crystallisation and their structures assigned by NOE difference spectroscopy.Reduction of the nitro group in each compound followed by acetylation and ester hydrolysis gave the isomeric acetamido acids 7 and 8, which were efficiently condensed with 3-(diemthylamino)phenol in the presence of trimethylsilyl polyphosphate to give the acetamidorhodamines 9 and 10, respectively.These compounds were converted by standard means into the pure 6- and 5-(iodoacetamido)tetramethylrhodamines 1 and 2.The visible spectroscopic properties of the compounds were examined and accurate extinction determined.