166442-37-1

Basic information

• Product Name: 5Acetamido-2carboxy-4-dimethylamino-2-hydroxybenzophenone
• Synonyms: 4-(AcetylaMino)-2-[4-(diMethylaMino)-2-hydroxybenzoyl]benzoic Acid
• CAS NO: 166442-37-1
• Molecular Formula: C₁₈H₁₈N₂O₅
• Molecular Weight: 342.35
• Product Categories: Miscellaneous Reagents;Amines;Aromatics;Fluorescent Labels & Indicators;Amines, Aromatics, Fluorescent Labels & Indicators
• Mol File: 166442-37-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 228-229°C dec.
• Boiling Point: 655.4°C at 760 mmHg
• Flash Point: 350.1°C
• Appearance: /
• Density: 1.371g/cm³
• Vapor Pressure: 4.55E-18mmHg at 25°C
• Refractive Index: 1.671
• CAS DataBase Reference: 5Acetamido-2carboxy-4-dimethylamino-2-hydroxybenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 5Acetamido-2carboxy-4-dimethylamino-2-hydroxybenzophenone(166442-37-1)
• EPA Substance Registry System: 5Acetamido-2carboxy-4-dimethylamino-2-hydroxybenzophenone(166442-37-1)

Safety Data

• Hazardous Substances Data: 166442-37-1(Hazardous Substances Data)

Usage

Chemical Properties

5Acetamido-2carboxy-4-dimethylamino-2-hydroxybenzophenone is Brown Plates

Uses

5Acetamido-2carboxy-4-dimethylamino-2-hydroxybenzophenone is an intermediate used for the preparation of rhodamine derivatives as fluorescent labels.

InChI:InChI=1/C18H18N2O5/c1-10(21)19-11-4-6-13(18(24)25)15(8-11)17(23)14-7-5-12(20(2)3)9-16(14)22/h4-9,22H,1-3H3,(H,19,21)(H,24,25)

Upstream product

• 159435-02-6 methyl 2-(4'-dimethylamino-2'-hydroxybenzoyl)-4-nitrobenzoate 
• 610-27-5 4-nitrophthalic acid 
• 5466-84-2 4-nitrophthalic anhydride 
• 108-24-7 acetic anhydride 
• 1026132-88-6 4-Amino-2-(4-dimethylamino-2-hydroxy-benzoyl)-benzoic acid methyl ester 

Downstream Products

• 159435-10-6 6-amino-3',6'-bis(dimethylamino)spiro<1,3-dihydroisobenzofuran-1,9'-xanthen>-3-one 
• 159435-00-4 6-iodoacetamido-3',6'-bis(dimethylamino)spiro<1,3-dihydroisobenzofuran-1,9'-xanthen>-3-one 
• 159435-08-2 6-chloroacetamido-3',6'-bis(dimethylamino)spiro<1,3-dihydroisobenzofuran-1,9'-xanthen>-3-one 

Relevant articles and documents

Synthesis and Characterisation of Pure Isomers of Iodoacetamidotetramethylrhodamine

The isomeric benzoylnitrobenzoate esters 5 and 6, prepared by condensation of 4-nitrophthalic anhydride and 3-(dimethylamino)phenol followed by esterification, were separated by fractional crystallisation and their structures assigned by NOE difference spectroscopy.Reduction of the nitro group in each compound followed by acetylation and ester hydrolysis gave the isomeric acetamido acids 7 and 8, which were efficiently condensed with 3-(diemthylamino)phenol in the presence of trimethylsilyl polyphosphate to give the acetamidorhodamines 9 and 10, respectively.These compounds were converted by standard means into the pure 6- and 5-(iodoacetamido)tetramethylrhodamines 1 and 2.The visible spectroscopic properties of the compounds were examined and accurate extinction determined.