1595073-50-9Relevant academic research and scientific papers
Synthesis of δ-lactone and amino acid frameworks utilizing the umpoled reactivity of β,γ-Alkenyl aα-iminoester
Kawanishi, Mami,Mizota, Isao,Aratake, Kana,Tanaka, Hirotaka,Nakahama, Kenta,Shimizu, Makoto
, p. 395 - 403 (2017)
An umpolung N-alkylation reaction of β,γ-alkenyl aα- iminoesters was studied, and various tandem reactions were found utilizing this N-alkylation. A useful synthesis of δ- lactones and dienamines was developed by tandem N-alkylation/ vinylogous aldol-type reaction. The synthesis of aα- quaternary alkenyl amino esters was also developed via the tandem N-alkylation/bromination/C-alkylation. These methods using β,γ-alkenyl aα-iminoesters are operationally simple and useful, and exhibit broad substrate generality.
Tandem N -alkylation/vinylogous aldol reaction of β,γ-Alkenyl α-iminoester
Tanaka, Hirotaka,Mizota, Isao,Shimizu, Makoto
supporting information, p. 2276 - 2279 (2014/05/06)
This report describes a highly regioselective tandem N-alkylation/ vinylogous aldol reaction of β,γ-alkenyl α-iminoesters. The sulfur group improves the regioselectivity of the directed vinylogous aldol reaction, providing a new synthetic method of 3-amino-2-pyrones.
