1595072-88-0

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 100-58-3 phenylmagnesium bromide 
• 2579-22-8 Phenylpropargyl aldehyde 
• 1121-60-4 pyridine-2-carbaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 
• 98-03-3 thiophene-2-carbaldehyde 
• 100-52-7 benzaldehyde 

Downstream Products

• 1595073-50-9 3-[ethyl(4-methoxyphenyl)amino]-5,5-diphenyl-6-(pyridin-2-yl)-5,6-dihydro-2H-pyran-2-one 
• 1595073-48-5 6-(4-chlorophenyl)-3-[ethyl(4-methoxyphenyl)amino]-5,5-diphenyl-5,6-dihydro-2H-pyran-2-one 
• 1595073-46-3 3-[ethyl(4-methoxyphenyl)amino]-6-(4-methoxyphenyl)-5,5-diphenyl-5,6-dihydro-2H-pyran-2-one 
• 1595073-17-8 3-[ethyl(4-methoxyphenyl)amino]-5,5,6-triphenyl-5,6-dihydro-2H-pyran-2-one 

Relevant academic research and scientific papers

Synthesis of δ-lactone and amino acid frameworks utilizing the umpoled reactivity of β,γ-Alkenyl aα-iminoester

An umpolung N-alkylation reaction of β,γ-alkenyl aα- iminoesters was studied, and various tandem reactions were found utilizing this N-alkylation. A useful synthesis of δ- lactones and dienamines was developed by tandem N-alkylation/ vinylogous aldol-type reaction. The synthesis of aα- quaternary alkenyl amino esters was also developed via the tandem N-alkylation/bromination/C-alkylation. These methods using β,γ-alkenyl aα-iminoesters are operationally simple and useful, and exhibit broad substrate generality.

Tandem N -alkylation/vinylogous aldol reaction of β,γ-Alkenyl α-iminoester

This report describes a highly regioselective tandem N-alkylation/ vinylogous aldol reaction of β,γ-alkenyl α-iminoesters. The sulfur group improves the regioselectivity of the directed vinylogous aldol reaction, providing a new synthetic method of 3-amino-2-pyrones.