159518-02-2Relevant academic research and scientific papers
Cephem sulfones as inactivators of human leukocyte elastase. 5. 7α- Methoxy- and 7α-chloro-1,1-dioxocephem 4-ketones
Alpegiani,Bissolino,Corigli,Del Nero,Perrone,Rizzo,Sacchi,Cassinelli,Franceschi,Baici
, p. 4003 - 4019 (2007/10/02)
Studies on cephem sulfones as inhibitors of human leukocyte elastase (HLE) have been extended to the new class of cephem 4-ketones. tert-Butyl and phenyl ketones were prepared from 4-carboxycephem derivatives, at either the sulfide or sulfone oxidation le
FUNCTIONALIZATION OF THE DIHYDROTHIAZINE RING OF CEPHEM SULFONES
Alpegiani, Marco,Bissolino, Pierluigi,Borghi, Daniela,Sbraletta, Pietro,Tonani, Roberto,Perrone, Ettore
, p. 1747 - 1762 (2007/10/02)
Functionalization of the dihydrothiazine ring of cephem esters and 4-ketones was studied at the sulfone oxidation level.On the esters, alkylation and MIchael addition gave 4β- and 2α,4β-substituted products.On the ketones, electrophilic insertion of carbo
