159554-47-9

Upstream product

• 159554-45-7 (3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile 
• 123944-74-1 (E)-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-hydroxybenzylamine 

Relevant academic research and scientific papers

Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: A new type of potent squalene epoxidase inhibitors

Sulfonamide derivatives of ene-yne benzylamine 1 have been prepared and identified as a new class of potent SE inhibitors having demonstrated activity in HepG2 cells as cholesterol biosynthesis inhibitors.

Comparative study of new and known thienyl derivatives of ene-yne benzylamine as mammalian squalene epoxidase inhibitors

Analogs of the well-known squalene epoxidase inhibitor (SE) NB-598 (2) have been prepared and tested as cholesterol biosynthesis inhibitors in HepG2 cells. Among the compounds tested, the vinylthiophene analog 4 and the tertiary amide derivative of thiophene 8 emerged as potent human SE inhibitors and probably bind to the enzyme in a very similar manner as NB-598 (2). Surprisingly enough, compounds 4 and 8, contrary to NB-598, are poor inhibitors of rat SE, thus further demonstrating major differences between mammalian enzymes from different species.