159564-92-8Relevant academic research and scientific papers
Dual-Emissive Platinum(II) Metallacage with a Sensitive Oxygen Response for Imaging of Hypoxia and Imaging-Guided Chemotherapy
Ge, Fujing,Huang, Feihe,Li, Qi,Liu, Yuezhou,Mao, Zhengwei,Shi, Bingbing,Stang, Peter J.,Wang, Sheng,Yu, Guocan,Zhu, Hong,Zhu, Huangtianzhi
, p. 20208 - 20214 (2020)
Imaging of hypoxia in vivo helps with accurate cancer diagnosis and evaluation of therapeutic outcomes. A PtII metallacage with oxygen-responsive red phosphorescence and steady fluorescence for in vivo hypoxia imaging and chemotherapy is reported. The therapeutic agent and diagnostic probe were integrated into the metallacage through heteroligation-directed self-assembly. Nanoformulation by encapsulating the metallacage into nanoparticles greatly enhanced its stability the in physiological environment, rendering biomedical applications feasible. Apart from enhanced red phosphorescence upon hypoxia, the ratio between red and blue emissions, which only varies with intracellular oxygen level, provides a more precise standard for hypoxia imaging and detection. Moreover, in vivo explorations demonstrate the promising potential applications of the metallacage-loaded nanoparticles as theranostic agents for tumor hypoxia imaging and chemotherapy.
Porphyrin-Based Metal-Organic Frameworks for Efficient Photocatalytic H2Production under Visible-Light Irradiation
Lin, Chenxiang,Han, Chaozheng,Zhang, Haijiao,Gong, Lei,Gao, Ying,Wang, Hailong,Bian, Yongzhong,Li, Renjie,Jiang, Jianzhuang
supporting information, p. 3988 - 3995 (2021/04/07)
Metal-organic frameworks (MOFs) are important photocatalytic materials for H2 production. To clarify the structure-function relationship and improve the photocatalytic activity, herein we explored a series of porphyrin-based zirconium MOFs (PCN-H2/Ptx:y, where x:y = 4:1, 3:2, 2:3, and 0:1) containing different ratios of H2TCPP and PtIITCPP [TCPP = tetrakis(4-carboxyphenyl)porphyrinate] as isostructural ligands and Zr6 clusters as nodes. Under visible-light irradiation, PCN-H2/Pt0:1 shows the highest average H2 evolution reaction rate (351.08 μmol h-1 g-1), which decreases along with lowering of the ratio of PtIITCPP in the PCN-H2/Ptx:y series. The differences in photocatalytic activity are attributed to more uniformly dispersed Pt2+ ions in PCN-H2/Pt0:1, which promotes charge transfer from porphyrins (photosensitizers) to PtII ions (catalytic centers), leading to efficient charge separation in the MOF materials. The bifunctional MOFs with photosensitizers and catalytic centers provide new insight for the design and application of porphyrin-based photocatalytic systems for visible-light-driven H2 production.
Dimerization, aggregation, and luminescent properties of palladium(II) and platinum(II) complexes with meso-tetrakis(4-carboxyphenyl)porphyrin
Vasil'ev,Borisov,Chubarova,Rumyantseva
, p. 385 - 390 (2008/10/08)
The synthesis of platinum(II) meso-tetrakis(4-carboxyphenyl)porphyrin has been developed. The palladium(II) and platinum(II) complexes with meso-tetrakis(4-carboxyphenyl)porphyrin exist as monomers in an ethylene glycol solution. In aqueous solutions, these complexes undergo dimerization and aggregation, which is supported by violations of the Beer law and by typical spectral changes. Dimerization equilibrium constants at various ionic strengths have been determined. Dimerization is promoted by the increase in the ionic strength of a solution and the decrease in its pH and temperature. The luminescent properties of the complexes have been studied. Dimerization of metalloporphyrins has virtually no effect on the phosphorescence quantum yield and lifetime, whereas aggregation considerably reduces these characteristics.
