1596-16-3Relevant articles and documents
SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF
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Page/Page column 29, (2010/04/23)
The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.
ORTHO-ALKYLATION OF o-, m-, AND p-CRESOLS WITH CYCLOHEXENE IN THE PRESENCE OF ALUMINUM CRESOLATES
Kozlikovskii, Ya. B.,Koshchii, V. A.,Butov, S. A.,Sokolova, A. V.
, p. 1702 - 1707 (2007/10/02)
The reaction of o-, m-, and p-cresols with cyclohexene in the presence of the corresponding aluminum cresolates leads to mixtures of ethers and phenols, in which the ortho-alkylation products, formed with yields of 75-85percent, predominate.
