1596-16-3

Upstream product

• 108-39-4 3-methyl-phenol 
• 108-93-0 cyclohexanol 
• 110-83-8 cyclohexene 
• 542-18-7 cyclohexyl chloride 
• 1596-15-2 (S)-Cyclohexyl-4-methoxy-2-methyl-benzene 

Downstream Products

• 111850-25-0 1,1,3-tris(3'-cyclohexyl-4'-hydroxy-6'-methylphenyl)butane 

Relevant academic research and scientific papers

SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.

Immunosuppressant Compounds and Compositions

The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.

ORTHO-ALKYLATION OF o-, m-, AND p-CRESOLS WITH CYCLOHEXENE IN THE PRESENCE OF ALUMINUM CRESOLATES

The reaction of o-, m-, and p-cresols with cyclohexene in the presence of the corresponding aluminum cresolates leads to mixtures of ethers and phenols, in which the ortho-alkylation products, formed with yields of 75-85percent, predominate.

Basic ethers of cyclohexylphenols with β blocking activity. Synthesis and pharmacological study of exaprolol

The paper discribes the preparation and study of the pharmacological properties of the basic ethers of cyclohexylphenols. The compounds with a single cycloaliphatic radical ortho to the basic chain, and in particular the one with a cyclohexyl (exaprolol), were found to be particularly active in blocking the β adrenergic receptors, as antiarrhythmics and local anesthetics, while the introduction of a second radical or the shift of the cycloaliphatic radical to meta or para position caused the said pharmacological activities to disappear almost entirely, with the exception of the local anesthetic action.