159622-29-4Relevant articles and documents
Chemoenzymatic route to β-blockers via 3-hydroxy esters
Wuensche, Kerstin,Schwaneberg, Ulrich,Bornscheuer, Uwe T.,Meyer, Hartmut H.
, p. 2017 - 2022 (2007/10/03)
Enantiomerically pure precursors of β-blockers (propranolol, alprenolol and 1-(isopropylamino)-3-p-methoxy-phenoxy-2-propanol) were synthesized. Key step is the lipase-catalyzed kinetic resolution of rac-3-hydroxy esters either by O-acylation using vinyl