159635-50-4

Basic information

• Product Name: N-Boc-N,N-bis(2-bromoethyl)amine
• Synonyms: N-Boc-N,N-bis(2-bromoethyl)amine;N-Boc-N,N-bis(2-broMoethy...;CarbaMic acid,bis(2-broMoethyl)-, 1,1-diMethylethyl ester (9CI);tert-Butyl bis(2-broMoethyl)carbaMate;tert-butyl N,N-bis(2-bromoethyl)carbamate
• CAS NO: 159635-50-4
• Molecular Formula: C₉H₁₇Br₂NO₂
• Molecular Weight: 331.06
• Mol File: 159635-50-4.mol

Chemical Properties

• Boiling Point: 317.7 °C at 760 mmHg
• Flash Point: 146 °C
• Appearance: /
• Density: 1.545 g/cm³
• Vapor Pressure: 0.000378mmHg at 25°C
• Refractive Index: 1.515
• PKA: -1.80±0.70(Predicted)
• CAS DataBase Reference: N-Boc-N,N-bis(2-bromoethyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-N,N-bis(2-bromoethyl)amine(159635-50-4)
• EPA Substance Registry System: N-Boc-N,N-bis(2-bromoethyl)amine(159635-50-4)

Safety Data

• Hazardous Substances Data: 159635-50-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-Boc-N,N-bis(2-bromoethyl)amine is used as a synthetic reagent for the creation of complex molecules in drug development. Its Boc group plays a crucial role in protecting amines, which is essential for the synthesis of certain pharmaceutical compounds.
Used in Specialty Chemicals Industry:
N-Boc-N,N-bis(2-bromoethyl)amine is used as a reagent in the synthesis of specialty chemicals, where its ability to protect amines is vital for the production of specific chemical entities. N-Boc-N,N-bis(2-bromoethyl)amine is particularly useful in the development of novel materials and compounds with unique properties.

InChI:InChI=1/C9H17Br2NO2/c1-9(2,3)14-8(13)12(6-4-10)7-5-11/h4-7H2,1-3H3

Upstream product

• 401518-11-4 [(tert-butoxycarbonyl)imino]diethane-2,1-diyl dimethanesulfonate 
• 3890-99-1 bis(2-bromoethyl)amine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 77278-63-8 4-phenyl-piperazine-1-carboxylic acid tert-butyl ester 
• 362697-41-4 1-[(1,1-dimethylethoxy)carbonyl]-N-hydroxy-4-[[[4-[(2-methyl-4-quinolinyl)methoxy]benzoyl]amino]methyl]-4-piperidinecarboxamide 
• 362703-36-4 4-{[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-methyl}-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester 
• 362703-35-3 1-tert-butyl 4-methyl 4-(aminomethyl)piperidine-1,4-dicarboxylate 
• 362703-34-2 1-tert-butyl 4-methyl 4-cyanopiperidine-1,4-dicarboxylate 
• 1228079-29-5 tert-butyl 1-oxo-1,3-dihydrospiro[indene-2,4’-piperidine]-1’-carboxylate 

Relevant articles and documents

Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4′-piperidine]

Cyclization of the benzoylpiperidine in lead compound 2 generated a series of novel and highly potent spiropiperidine-based stearoyl-CoA desaturase (SCD)-1 inhibitors. Among them, 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4′-piperidine] (19) demonstrated the most powerful inhibitory activity against SCD-1, not only in vitro but also in vivo (C57BL/6 J mice). With regard to the pharmacological evaluation, 19 showed powerful reduction of the desaturation index in the plasma of C57BL/6 J mice on a non-fat diet after a 7-day oral administration (q.d.) without causing notable abnormalities in the eyes or skin up to the highest dose (3 mg/kg) in our preliminary analysis.

Potent 3-spiropiperidine growth hormone secretagogues

Systematic SAR studies of the different regioisomers and homologues of the spiro(indane-1,4'-piperidine) moiety in the growth hormone secretagogue L-162,752 are presented. Among them, spiro(3H-1-benzopyran-2,3'-piperidine) was found to afford secretagogue